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Pde4b phosphodiesterase 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 24626, updated on 3-Jun-2026
Symbol
Pde4bprovided by RGD
Full Name
phosphodiesterase 4Bprovided by RGD
Primary source
RGD:3280
See related
Ensembl:ENSRNOG00000005905 AllianceGenome:RGD:3280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pde4B1; Pde4B2; Pde4B3; Pde4B4; Pde4b5; PDE4/IVb; Pde4b_v1; Pde4b_v2; Pde4b_v3; Pde4b_v4
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in T cell receptor signaling pathway; cAMP-mediated signaling; and positive regulation of cytokine production. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and neutrophil homeostasis. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human PDE4B (phosphodiesterase 4B). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Brain (RPKM 181.0), Heart (RPKM 165.9) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Pde4b in Genome Data Viewer
Location:
5q33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (122028956..122598267)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (116799819..117369155)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (121759236..122136814)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486956 Neighboring gene uncharacterized LOC120103168 Neighboring gene oogenesin 3 like 2 Neighboring gene uncharacterized LOC103692427 Neighboring gene uncharacterized LOC102548249 Neighboring gene uncharacterized LOC134486957 Neighboring gene SH3GL interacting endocytic adaptor 1 Neighboring gene dynein light chain Tctex-type family member 5

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling. Pan Z, et al. Biomed Pharmacother, 2023 Feb. PMID 36495666
  2. Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury. Whitaker CM, et al. Neurosci Lett, 2008 Jun 20. PMID 18455876, Free PMC Article
  3. Renal phosphodiesterase 4B is activated in the Dahl salt-sensitive rat. Tawar U, et al. Hypertension, 2008 Mar. PMID 18227403
  4. Selective induction of cAMP phosphodiesterase PDE4B2 expression in experimental autoimmune encephalomyelitis. Reyes-Irisarri E, et al. J Neuropathol Exp Neurol, 2007 Oct. PMID 17917586
  5. Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Kim JS, et al. Endocrinology, 2007 Apr. PMID 17204557

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1alpha signaling.
    Title: Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling.
  2. Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects.
    Title: Fibroblast growth factor 23 decreases PDE4 expression in heart increasing the risk of cardiac arrhythmia; Klotho opposes these effects.
  3. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
    Title: Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase.
  4. PDE4B is primarily responsible for muscle proteolysis in burn injury and it, thus, constitutes a unique target for selective manipulations with drugs to control muscle cachexia.
    Title: Phosphodiesterase 4B knockout prevents skeletal muscle atrophy in rats with burn injury.
  5. The mRNA expression of PDE4D was significantly increased in allergic rats, but PDE4B was not. PDE4B was mainly distributed in the cytoplasm, whereas PDE4D was mainly distributed in the cell membrane
    Title: Anti‑inflammatory effect of ciclamilast in an allergic model involving the expression of PDE4B.
  6. PDE4B mediates a crucial PKA-dependent feedback that controls beta1 adrenergic receptor-dependent cAMP signals in a restricted subsarcolemmal domain.
    Title: PDE4B mediates local feedback regulation of β₁-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes.
  7. Upregulated PDE4 expression during cholestatic liver injury plays a potential pathogenic role in the development of inflammation and fibrosis.
    Title: Rolipram attenuates bile duct ligation-induced liver injury in rats: a potential pathogenic role of PDE4.
  8. Acutely after spinal cord injury, PDE4B is localized to activated microglia and is absent in uninjured spinal cord or inactive microglia.
    Title: Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microglia in vitro and following CNS injury.
  9. PDE3a, PDE4b and PDE4d isoforms mRNAs were highly expressed in the whole cervical ganglia with no modulation by hypoxia.
    Title: Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia.
  10. ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2
    Title: ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.
Submit: New GeneRIF Correction See all GeneRIFs (22)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC93193

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP/PKA signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neutrophil homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
  
part_of gamma-tubulin complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
3',5'-cyclic-AMP phosphodiesterase 4B
Names
3',5'-cyclic AMP phosphodiesterase
DPDE4
Phosphodiesterase 4B, cAMP-specific (dunce
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
cAMP-specific phosphodiesterase 4B
phosphodiesterase 4B, cAMP specific
phosphodiesterase type 4B5
NP_001385864.1
NP_058727.3
XP_038965200.1
XP_038965202.1
XP_038965203.1
XP_063143230.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398935.2 → NP_001385864.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P14646, Q5RKL0, Q8VD81, Q8VD82
    UniProtKB/TrEMBL
    A0A8I5ZY41, A6JRQ8
    Related
    ENSRNOP00000084515.1, ENSRNOT00000099065.2
    Conserved Domains (2) summary
    pfam00233
    Location:405 → 646
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:166 → 281
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  2. NM_001429342.1 → NP_001416271.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AT13, A6JRR1, F1M1T9

  3. NM_017031.4 → NP_058727.3  3',5'-cyclic-AMP phosphodiesterase 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6JRQ9, D3ZLB2, F1M1T9
    Related
    ENSRNOP00000008278.6, ENSRNOT00000008278.8
    Conserved Domains (2) summary
    pfam00233
    Location:390 → 631
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:151 → 266
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    122028956..122598267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109275.2 → XP_038965203.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X3

    Conserved Domains (2) summary
    pfam18100
    Location:166 → 281
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
    cl21469
    Location:405 → 428
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

  2. XM_039109272.2 → XP_038965200.1  

    Related
    ENSRNOP00000096704.2, ENSRNOT00000098470.2
    Conserved Domains (2) summary
    pfam00233
    Location:328 → 569
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:89 → 204
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  3. XM_039109274.2 → XP_038965202.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q3F0, A6JRR2
    Related
    ENSRNOP00000007738.5, ENSRNOT00000007738.8
    Conserved Domains (2) summary
    pfam00233
    Location:172 → 413
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:16 → 48
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

  4. XM_063287160.1 → XP_063143230.1  3',5'-cyclic-AMP phosphodiesterase 4B isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14646.4 GenPept UniProtKB/Swiss-Prot:P14646

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