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Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 246211, updated on 21-Jul-2018

Summary

Official Symbol
Hsd3b7provided by RGD
Official Full Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7provided by RGD
Primary source
RGD:628727
See related
Ensembl:ENSRNOG00000019080
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cca2
Summary
protein that is expressed in under growth-arrest conditions [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 642.2), Adrenal (RPKM 146.1) and 8 other tissues See more
Orthologs

Genomic context

See Hsd3b7 in Genome Data Viewer
Location:
1q37
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199248084..199251745)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (206270509..206274641)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC108349648

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
B cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
B cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
B cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
bile acid metabolic process TAS
Traceable Author Statement
more info
PubMed 
cholesterol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
lipid droplet IEA
Inferred from Electronic Annotation
more info
 
lipid droplet ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3 beta-hydroxysteroid dehydrogenase type 7
Names
3 beta-hydroxysteroid dehydrogenase type VII
3-beta-HSD VII
3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase
c(27) 3-beta-HSD
cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase
confluent 3Y1 cell-associated 2
NP_647545.1
XP_006230274.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139329.1NP_647545.1  3 beta-hydroxysteroid dehydrogenase type 7

    See identical proteins and their annotated locations for NP_647545.1

    Status: PROVISIONAL

    Source sequence(s)
    AB000199
    UniProtKB/Swiss-Prot
    O35048
    Related
    ENSRNOP00000025933.4, ENSRNOT00000025933.4
    Conserved Domains (2) summary
    pfam01073
    Location:13252
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:11330
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    199248084..199251745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230212.3XP_006230274.1  3 beta-hydroxysteroid dehydrogenase type 7 isoform X1

    See identical proteins and their annotated locations for XP_006230274.1

    Conserved Domains (2) summary
    pfam01073
    Location:13283
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    cl21454
    Location:11361
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    180063215..180066485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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