U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mllt6 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 [ Mus musculus (house mouse) ]

Gene ID: 246198, updated on 26-Sep-2022

Summary

Official Symbol
Mllt6provided by MGI
Official Full Name
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6provided by MGI
Primary source
MGI:MGI:1935145
See related
Ensembl:ENSMUSG00000038437 AllianceGenome:MGI:1935145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Af17
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within several processes, including negative regulation of histone H3-K79 methylation; renal potassium excretion; and renal sodium excretion. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; forelimb bud; genitourinary system; nervous system; and sensory organ. Orthologous to human MLLT6 (MLLT6, PHD finger containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 32.0), lung adult (RPKM 28.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mllt6 in Genome Data Viewer
Location:
11 D; 11 61.05 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97553948..97576287)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97663122..97685461)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene elongin BC and polycomb repressive complex 2 associated protein Neighboring gene predicted gene 11613 Neighboring gene microRNA 6927 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene polycomb group ring finger 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosome binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein AF-17
Names
myeloid/lymphoid or mixed lineage-leukemia translocation to 6 homolog
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139311.2NP_647472.2  protein AF-17

    See identical proteins and their annotated locations for NP_647472.2

    Status: VALIDATED

    Source sequence(s)
    AK143477, AK143814, AL596123, BY731745
    Consensus CDS
    CCDS25323.1
    UniProtKB/TrEMBL
    B1AR09, Q3UPK1
    Related
    ENSMUSP00000045445.6, ENSMUST00000044730.12
    Conserved Domains (2) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97553948..97576287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533332.3XP_006533395.1  protein AF-17 isoform X1

    UniProtKB/TrEMBL
    B1AR10
    Related
    ENSMUSP00000103212.3, ENSMUST00000107586.3
    Conserved Domains (4) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    pfam10500
    Location:229329
    SR-25; Nuclear RNA-splicing-associated protein
    cl23880
    Location:737763
    HALZ; Homeobox associated leucine zipper
  2. XM_006533335.3XP_006533398.1  protein AF-17 isoform X3

    Conserved Domains (4) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    pfam10500
    Location:229329
    SR-25; Nuclear RNA-splicing-associated protein
    cl23880
    Location:737763
    HALZ; Homeobox associated leucine zipper
  3. XM_006533333.3XP_006533396.1  protein AF-17 isoform X2

    Conserved Domains (4) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61184
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    pfam10500
    Location:228328
    SR-25; Nuclear RNA-splicing-associated protein
    cl23880
    Location:736762
    HALZ; Homeobox associated leucine zipper
  4. XM_036156705.1XP_036012598.1  protein AF-17 isoform X4

    Conserved Domains (3) summary
    cd15574
    Location:754
    PHD_AF10_AF17; PHD finger found in protein AF-10 and AF-17
    cd15709
    Location:61185
    ePHD_AF17; Extended PHD finger found in protein AF-17 and similar proteins
    cd20901
    Location:719773
    CC_AF10; coiled coil domain of ALL1-Fused gene from chromosome 10 protein (AF10) and similar proteins