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GAS2L2 growth arrest specific 2 like 2 [ Homo sapiens (human) ]

Gene ID: 246176, updated on 23-Nov-2021

Summary

Official Symbol
GAS2L2provided by HGNC
Official Full Name
growth arrest specific 2 like 2provided by HGNC
Primary source
HGNC:HGNC:24846
See related
Ensembl:ENSG00000270765 MIM:611398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAR17; CILD41
Summary
The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]
Expression
Biased expression in lung (RPKM 1.4), fat (RPKM 0.6) and 5 other tissues See more
Orthologs
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Genomic context

See GAS2L2 in Genome Data Viewer
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (35744511..35753239, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34071530..34080258, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene RAS like family 10 member B Neighboring gene uncharacterized LOC107985067 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene TATA-box binding protein associated factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with ciliary basal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule plus-end IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GAS2-like protein 2
Names
GAS2-related protein on chromosome 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029638.1 RefSeqGene

    Range
    4640..13368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139285.4NP_644814.1  GAS2-like protein 2

    See identical proteins and their annotated locations for NP_644814.1

    Status: REVIEWED

    Source sequence(s)
    AC006237
    Consensus CDS
    CCDS11298.1
    UniProtKB/Swiss-Prot
    Q8NHY3
    Related
    ENSP00000474529.2, ENST00000604641.6
    Conserved Domains (2) summary
    cd00014
    Location:34159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:207274
    GAS2; Growth-Arrest-Specific Protein 2 Domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    35744511..35753239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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