U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GAS2L2 growth arrest specific 2 like 2 [ Homo sapiens (human) ]

Gene ID: 246176, updated on 11-Jun-2025
Official Symbol
GAS2L2provided by HGNC
Official Full Name
growth arrest specific 2 like 2provided by HGNC
Primary source
HGNC:HGNC:24846
See related
Ensembl:ENSG00000270765 MIM:611398; AllianceGenome:HGNC:24846
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAR17; CILD41
Summary
The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]
Expression
Biased expression in lung (RPKM 1.4), fat (RPKM 0.6) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See GAS2L2 in Genome Data Viewer
Location:
17q12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35744511..35753239, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36692448..36701176, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34071530..34080258, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene Sharpr-MPRA regulatory region 1039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34059551-34060074 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene RAS like family 10 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34092667-34093167 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34121971-34122509 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34136503-34137204 Neighboring gene TATA-box binding protein associated factor 15

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal anchor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytoskeletal anchor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule depolymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to microtubule plus-end IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium beat frequency involved in ciliary motility IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium beat frequency involved in ciliary motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with actin filament IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ciliary basal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with microtubule plus-end IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
GAS2-like protein 2
Names
GAS2-related protein on chromosome 17

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029638.1 RefSeqGene

    Range
    4640..13368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139285.4NP_644814.1  GAS2-like protein 2

    See identical proteins and their annotated locations for NP_644814.1

    Status: REVIEWED

    Source sequence(s)
    AC006237
    Consensus CDS
    CCDS11298.1
    UniProtKB/Swiss-Prot
    Q8NHY3, Q8NHY4
    Related
    ENSP00000474529.2, ENST00000604641.6
    Conserved Domains (2) summary
    cd00014
    Location:34159
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam02187
    Location:207274
    GAS2; Growth-Arrest-Specific Protein 2 Domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35744511..35753239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36692448..36701176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)