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CNOT6L CCR4-NOT transcription complex subunit 6 like [ Homo sapiens (human) ]

Gene ID: 246175, updated on 29-Mar-2020

Summary

Official Symbol
CNOT6Lprovided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 6 likeprovided by HGNC
Primary source
HGNC:HGNC:18042
See related
Ensembl:ENSG00000138767 MIM:618069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCR4b
Expression
Ubiquitous expression in lymph node (RPKM 12.1), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See CNOT6L in Genome Data Viewer
Location:
4q21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (77713387..77820269, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (78634541..78740764, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 13 Neighboring gene uncharacterized LOC105377296 Neighboring gene uncharacterized LOC105377297 Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene uncharacterized LOC102724916 Neighboring gene serine and arginine rich splicing factor 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A)-specific ribonuclease activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
mRNA destabilization IEA
Inferred from Electronic Annotation
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytoplasmic mRNA processing body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 6-like
Names
carbon catabolite repressor protein 4 homolog B
NP_001273719.1
NP_001351935.1
NP_001351936.1
NP_653172.2
XP_011530108.1
XP_011530109.1
XP_011530110.1
XP_011530111.1
XP_016863446.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286790.2NP_001273719.1  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_001273719.1

    Status: VALIDATED

    Source sequence(s)
    AC104701, AK303417, AL133112
    Consensus CDS
    CCDS68731.1
    UniProtKB/Swiss-Prot
    Q96LI5
    UniProtKB/TrEMBL
    B4E0K8
    Related
    ENSP00000424896.1, ENST00000504123.6
    Conserved Domains (3) summary
    cd10312
    Location:191538
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3857
    LRR_1; leucine-rich repeat [structural motif]
  2. NM_001365006.1NP_001351935.1  CCR4-NOT transcription complex subunit 6-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104701
    Conserved Domains (3) summary
    cd10312
    Location:186541
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5375
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_001365007.1NP_001351936.1  CCR4-NOT transcription complex subunit 6-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104701
    Conserved Domains (3) summary
    cd10312
    Location:186541
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5375
    LRR_RI; leucine-rich repeat [structural motif]
  4. NM_144571.3NP_653172.2  CCR4-NOT transcription complex subunit 6-like isoform 1

    See identical proteins and their annotated locations for NP_653172.2

    Status: VALIDATED

    Source sequence(s)
    AC104701, AL133112, DA043791, DB454180
    UniProtKB/Swiss-Prot
    Q96LI5
    Conserved Domains (3) summary
    cd10312
    Location:191538
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3857
    LRR_1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    77713387..77820269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531806.3XP_011530108.1  CCR4-NOT transcription complex subunit 6-like isoform X1

    Conserved Domains (4) summary
    cd10312
    Location:230585
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    sd00033
    Location:97119
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:95135
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:95176
    LRR_8; Leucine rich repeat
  2. XM_011531807.3XP_011530109.1  CCR4-NOT transcription complex subunit 6-like isoform X2

    Conserved Domains (4) summary
    cd10312
    Location:230577
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    sd00033
    Location:97119
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:95135
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:95176
    LRR_8; Leucine rich repeat
  3. XM_011531809.1XP_011530111.1  CCR4-NOT transcription complex subunit 6-like isoform X4

    See identical proteins and their annotated locations for XP_011530111.1

    Conserved Domains (3) summary
    cd10312
    Location:191546
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5880
    LRR_RI; leucine-rich repeat [structural motif]
  4. XM_011531808.2XP_011530110.1  CCR4-NOT transcription complex subunit 6-like isoform X3

    See identical proteins and their annotated locations for XP_011530110.1

    Conserved Domains (3) summary
    cd10312
    Location:191546
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:57183
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5880
    LRR_RI; leucine-rich repeat [structural motif]
  5. XM_017007957.2XP_016863446.1  CCR4-NOT transcription complex subunit 6-like isoform X6

    Related
    ENSP00000497467.1, ENST00000649644.1
    Conserved Domains (3) summary
    cd10312
    Location:186533
    Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
    COG4886
    Location:52178
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:3352
    LRR_1; leucine-rich repeat [structural motif]
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