U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Orm1 orosomucoid 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24614, updated on 5-Aug-2022

Summary

Official Symbol
Orm1provided by RGD
Official Full Name
orosomucoid 1provided by RGD
Primary source
RGD:67390
See related
Ensembl:ENSRNOG00000007886 AllianceGenome:RGD:67390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
AAG; AGP; OMD; Orm; Agpa1
Summary
Enables small molecule binding activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to retinoic acid; and inflammatory response to antigenic stimulus. Located in extracellular space. Orthologous to several human genes including ORM1 (orosomucoid 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 4784.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Orm1 in Genome Data Viewer
Location:
5q24
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (76766637..76776149)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (79179668..79182820)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 12 Neighboring gene collagen type XXVII alpha 1 chain Neighboring gene microRNA 455 Neighboring gene uncharacterized LOC102547858 Neighboring gene AT-hook transcription factor Neighboring gene whirlin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables small molecule binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in acute inflammatory response to antigenic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chronic inflammatory response to antigenic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053288.2NP_445740.1  alpha-1-acid glycoprotein precursor

    See identical proteins and their annotated locations for NP_445740.1

    Status: PROVISIONAL

    Source sequence(s)
    J00696
    UniProtKB/Swiss-Prot
    P02764
    Related
    ENSRNOP00000010454.2, ENSRNOT00000010454.5
    Conserved Domains (1) summary
    cd19451
    Location:21190
    lipocalin_AGP-like; alpha1-acid glycoprotein and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    76766637..76776149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109268.1XP_038965196.1  alpha-1-acid glycoprotein isoform X1

    UniProtKB/Swiss-Prot
    P02764
    Conserved Domains (1) summary
    cd19451
    Location:21190
    lipocalin_AGP-like; alpha1-acid glycoprotein and similar proteins