Oprd1 opioid receptor, delta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oprd1provided by RGD
Official Full Name: opioid receptor, delta 1provided by RGD
Primary source: RGD:3233
See related: Ensembl:ENSRNOG00000010531 AllianceGenome:RGD:3233
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G protein-coupled enkephalin receptor activity and receptor serine/threonine kinase binding activity. Involved in several processes, including eating behavior; response to ethanol; and response to nicotine. Located in several cellular components, including axon terminus; dendrite membrane; and postsynaptic membrane. Is active in secretory vesicle; spine apparatus; and synaptic membrane. Used to study alcohol use disorder and myocardial infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; drug dependence (multiple); opioid abuse; and withdrawal disorder. Orthologous to human OPRD1 (opioid receptor delta 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 15.8) and Kidney (RPKM 2.9) See more
Orthologs: all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (149590244..149624999, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (144306188..144340960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (150288126..150323063, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Central delta/kappa opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation.
Title: Central δ/κ opioid receptor signaling pathways mediate chronic and/or acute suckling-induced LH suppression in rats during late lactation.
Enkephalin-delta Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats.
Title: Enkephalin-δ Opioid Receptor Signaling Mediates Glucoprivic Suppression of LH Pulse and Gluconeogenesis in Female Rats.
Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
Title: Distribution of delta and mu opioid receptor mRNA in rodent dorsal root ganglia neurons.
delta-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
Title: δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
Role of miR-326 in neonatal hypoxic-ischemic brain damage pathogenesis through targeting of the delta-opioid receptor.
Title: Role of miR-326 in neonatal hypoxic-ischemic brain damage pathogenesis through targeting of the δ-opioid receptor.
These findings increase the knowledge of neuropathic pain development and the role of spinal astrocytic Cx43, suggesting new approaches for the treatment of neuropathic pain.
Title: Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain.
Delta opioid receptor plays an important role in protecting against hypoxia-ischemia by regulating the expression of inflammatory mediators in the cortex.
Title: δ-Opioid Receptor-Nrf-2-Mediated Inhibition of Inflammatory Cytokines in Neonatal Hypoxic-Ischemic Encephalopathy.
DOR attenuates the formation of toxic alpha-synuclein oligomers through the phos-CREB pathway under hypoxic conditions, and through TORC1/SIK1/CREB pathways in the conditions of alpha-synuclein overexpression and mutation.
Title: δ-Opioid Receptor Activation Attenuates the Oligomer Formation Induced by Hypoxia and/or α-Synuclein Overexpression/Mutation Through Dual Signaling Pathways.
These data suggests a unique mechanism underlying DOR-mediated cytoprotection against hypoxic and 1-methyl-4-phenyl-pyridimium(+) stress via a PINK1-mediated regulation of signaling.
Title: δ-Opioid Receptor Activation Attenuates Hypoxia/MPP(+)-Induced Downregulation of PINK1: a Novel Mechanism of Neuroprotection Against Parkinsonian Injury.
Results showed that sexual experience acquisition improved male's copulatory ability and induced persistent changes in the density, cellular distribution and activation of MOR and beta-arrestin2 in Ventral Tegmental Area neurons. DOR density was not modified, but its cellular location changed after sexual experience.
Title: Opioid receptor and β-arrestin2 densities and distribution change after sexual experience in the ventral tegmental area of male rats.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94603 (e-PCR)
- UniSTS:119851

GDB:511375 (e-PCR)
- UniSTS:157503

BE119486 (e-PCR)
- UniSTS:249196

d5mgh21 (e-PCR)
- UniSTS:120459

d5rat103 (e-PCR)
- UniSTS:122075

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled enkephalin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled enkephalin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled enkephalin receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled enkephalin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled opioid receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled opioid receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in spine apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delta-type opioid receptor

Names: D-OR-1; DOR-1; opioid receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012617.1 → NP_036749.1 delta-type opioid receptor

See identical proteins and their annotated locations for NP_036749.1

Status: PROVISIONAL

Source sequence(s)

D16348

UniProtKB/Swiss-Prot

P33533

Related

ENSRNOP00000014084.2, ENSRNOT00000014084.5

Conserved Domains (2) summary

pfam00001
Location:66 → 318

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:59 → 232

7tm_4; Olfactory receptor