Cdkn1c cyclin-dependent kinase inhibitor 1C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdkn1cprovided by RGD
Official Full Name: cyclin-dependent kinase inhibitor 1Cprovided by RGD
Primary source: RGD:727892
See related: Ensembl:ENSRNOG00000059500 AllianceGenome:RGD:727892
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p57; Kip2; p57KIP2
Summary: Predicted to enable protein kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cyclin-dependent protein kinase activity; positive regulation of transforming growth factor beta receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including embryonic placenta morphogenesis; regulation of gene expression; and uterus development. Predicted to be located in cytoplasm and nucleus. Used to study lung cancer. Biomarker of lung cancer. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Adrenal (RPKM 410.1), Muscle (RPKM 232.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (208084801..208087680, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (198655394..198658097, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (216661067..216663791, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR2213p exacerbated the hydrogen peroxideinduced myocardial damage in H9c2 cells and myocardial ischemiareperfusion injury in the rat model by modulating p57.
Title: MicroRNA‑221‑3p contributes to cardiomyocyte injury in H2O2‑treated H9c2 cells and a rat model of myocardial ischemia‑reperfusion by targeting p57.
The results indicate enrichment of repressive chromatin histone marks and of the Polycomb PRC2 complex at the Runx2/p57 promoter region during epigenetic silencing of a critical osteogenic master regulator in the hippocampus.
Title: Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus.
The decrease of Cdkn1c induced by Ang II is mediated by AT1 receptors not AT2 receptors, since it is reversed by losartan.
Title: Losartan reverses the down-expression of long noncoding RNA-NR024118 and Cdkn1c induced by angiotensin II in adult rat cardiac fibroblasts.
Dexamethasone induced placental and embryonal abnormalities which could be associated with reduced expressions of PCNA and cyclin D3, increased expressions of p27 and p57 and increased rate of apoptosis in IUGR placentas
Title: Determination of PCNA, cyclin D3, p27, p57 and apoptosis rate in normal and dexamethasone-induced intrauterine growth restricted rat placentas.
Short-hairpin RNA-mediated suppression of p57kip2 in cultured adult neural stem cells was found to strongly reduce astroglial characteristics, while oligodendroglial precursor features were increased.
Title: p57kip2 regulates glial fate decision in adult neural stem cells.
p57(Kip2) coordinates multiple stages of corticogenesis and exhibits distinct and common activities compared with related family member p27(Kip1).
Title: The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors.
Suggest p57 may play a role in abnormal placental formation resulting in placentomegaly arising from diabetes.
Title: Cell cycle inhibitor p57 expression in normal and diabetic rat placentas during some stages of pregnancy.
This review is a thorough analysis of data available on p57(KIP2), on gene and protein structure, its transcriptional and translational regulation, and its role in human physiology and pathology, focusing on cancer development.
Title: p57KIP2: "Kip"ing the cell under control.
The p57kip2 gene is dynamically regulated in the spinal cord during MOG-induced experimental autoimmune encephalomyelitis.
Title: p57kip2 is dynamically regulated in experimental autoimmune encephalomyelitis and interferes with oligodendroglial maturation.
p57Kip2 exhibits nuclear expression as precursors exit the cell cycle and begin expressing neuronal characteristics suggests that the CDK inhibitor contributes to regulating the transition from proliferation to differentiation during brain development.
Title: Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:532227

MARC_54883-54884:1155673702:1 (e-PCR)
- UniSTS:508166

UniSTS:265486 (e-PCR)
- UniSTS:265486

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:265486

UniSTS:470552 (e-PCR)
- UniSTS:470552

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:470552

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:516696

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:516445

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:516463

PMC187562P1 (e-PCR)
- UniSTS:271730

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:516470

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:525478

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:532134

PMC307617P1 (e-PCR)
- UniSTS:272580

BI285996 (e-PCR)
- UniSTS:244940

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:141309

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:141310

UniSTS:141311 (e-PCR)
- UniSTS:141311

Cdkn1c (e-PCR), detects polymorphism
- UniSTS:141311

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adrenal gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adrenal gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic placenta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within genomic imprinting	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within genomic imprinting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of exit from mitosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lens fiber cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-dependent kinase inhibitor 1C

Names: cyclin-dependent kinase inhibitor p57; p57KIP2 A3sh

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033757.1 → NP_001028929.1 cyclin-dependent kinase inhibitor 1C isoform 1

See identical proteins and their annotated locations for NP_001028929.1

Status: VALIDATED

Source sequence(s)

AY351678, AY351679, BC098646, CF110214

UniProtKB/TrEMBL

A0A0G2K5Z5, Q69DC1

Conserved Domains (1) summary

pfam02234
Location:34 → 80

CDI; Cyclin-dependent kinase inhibitor
NM_001033758.1 → NP_001028930.1 cyclin-dependent kinase inhibitor 1C isoform 2

See identical proteins and their annotated locations for NP_001028930.1

Status: VALIDATED

Source sequence(s)

AY351679, BC098646

UniProtKB/TrEMBL

E9PTV7, Q69DC0

Conserved Domains (2) summary

PTZ00341
Location:165 → 280

PTZ00341; Ring-infected erythrocyte surface antigen; Provisional

pfam02234
Location:35 → 81

CDI; Cyclin-dependent kinase inhibitor
NM_182735.2 → NP_877399.2 cyclin-dependent kinase inhibitor 1C isoform 2

See identical proteins and their annotated locations for NP_877399.2

Status: VALIDATED

Source sequence(s)

BC098646, CB775146

UniProtKB/TrEMBL

E9PTV7, Q69DC0

Related

ENSRNOP00000074510.1, ENSRNOT00000077409.3

Conserved Domains (2) summary

PTZ00341
Location:165 → 280

PTZ00341; Ring-infected erythrocyte surface antigen; Provisional

pfam02234
Location:35 → 81

CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

208084801..208087680 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008760077.4 → XP_008758299.1 cyclin-dependent kinase inhibitor 1C isoform X1

See identical proteins and their annotated locations for XP_008758299.1

UniProtKB/TrEMBL

A0A0G2K5Z5, Q69DC1

Conserved Domains (1) summary

pfam02234
Location:34 → 80

CDI; Cyclin-dependent kinase inhibitor
XM_063280907.1 → XP_063136977.1 cyclin-dependent kinase inhibitor 1C isoform X2

UniProtKB/TrEMBL

E9PTV7, Q69DC0
XM_008760076.4 → XP_008758298.1 cyclin-dependent kinase inhibitor 1C isoform X1

See identical proteins and their annotated locations for XP_008758298.1

UniProtKB/TrEMBL

A0A0G2K5Z5, Q69DC1

Conserved Domains (1) summary

pfam02234
Location:34 → 80

CDI; Cyclin-dependent kinase inhibitor
XM_063280921.1 → XP_063136991.1 cyclin-dependent kinase inhibitor 1C isoform X4

UniProtKB/TrEMBL

Q6KF59
XM_008760079.4 → XP_008758301.1 cyclin-dependent kinase inhibitor 1C isoform X3

See identical proteins and their annotated locations for XP_008758301.1

UniProtKB/TrEMBL

A6HYB5

Conserved Domains (1) summary

pfam02234
Location:21 → 67

CDI; Cyclin-dependent kinase inhibitor
XM_063280917.1 → XP_063136987.1 cyclin-dependent kinase inhibitor 1C isoform X4

UniProtKB/TrEMBL

Q6KF59
XM_008760078.4 → XP_008758300.1 cyclin-dependent kinase inhibitor 1C isoform X3

See identical proteins and their annotated locations for XP_008758300.1

UniProtKB/TrEMBL

A6HYB5

Conserved Domains (1) summary

pfam02234
Location:21 → 67

CDI; Cyclin-dependent kinase inhibitor
XM_063280913.1 → XP_063136983.1 cyclin-dependent kinase inhibitor 1C isoform X4

UniProtKB/TrEMBL

Q6KF59
XM_063280912.1 → XP_063136982.1 cyclin-dependent kinase inhibitor 1C isoform X4

UniProtKB/TrEMBL

Q6KF59