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Nos3 nitric oxide synthase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24600, updated on 12-Aug-2018
Official Symbol
Nos3provided by RGD
Official Full Name
nitric oxide synthase 3provided by RGD
Primary source
RGD:3186
See related
Ensembl:ENSRNOG00000009348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
eNos
Summary
enzyme that synthesizes Nitric oxide from L-arginine [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 114.2), Spleen (RPKM 51.1) and 8 other tissues See more
Orthologs
See Nos3 in Genome Data Viewer
Location:
4q11
Exon count:
26
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7321908..7342404, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (7333272..7353767, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene acid sensing ion channel subunit 3 Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene autophagy related 9B Neighboring gene potassium voltage-gated channel subfamily H member 2 Neighboring gene uncharacterized LOC102554730

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
FMN binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin monomer binding IEA
Inferred from Electronic Annotation
more info
 
actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
arginine binding IEA
Inferred from Electronic Annotation
more info
 
arginine binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
PubMed 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
tetrahydrobiopterin binding IEA
Inferred from Electronic Annotation
more info
 
tetrahydrobiopterin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
arginine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arginine catabolic process IEA
Inferred from Electronic Annotation
more info
 
arginine catabolic process ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
bone development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to high density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to magnesium ion IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to rotenone IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to transforming growth factor beta stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
endocardial cushion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
lung development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of biomineral tissue development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of muscle hyperplasia IEA
Inferred from Electronic Annotation
more info
 
negative regulation of muscle hyperplasia ISO
Inferred from Sequence Orthology
more info
 
negative regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
ovulation from ovarian follicle ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
pulmonary valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of blood vessel size IEA
Inferred from Electronic Annotation
more info
 
regulation of blood vessel size ISO
Inferred from Sequence Orthology
more info
 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of systemic arterial blood pressure by endothelin IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by endothelin ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction by chemical signal IEA
Inferred from Electronic Annotation
more info
 
regulation of the force of heart contraction by chemical signal ISO
Inferred from Sequence Orthology
more info
 
removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
 
removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
response to L-arginine IEP
Inferred from Expression Pattern
more info
PubMed 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
response to axon injury IEP
Inferred from Expression Pattern
more info
PubMed 
response to candesartan IEP
Inferred from Expression Pattern
more info
PubMed 
response to carbohydrate IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to erythropoietin IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
response to fructose IEP
Inferred from Expression Pattern
more info
PubMed 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to ketone IEP
Inferred from Expression Pattern
more info
PubMed 
response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to magnetism IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to metformin IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
response to salt IEP
Inferred from Expression Pattern
more info
PubMed 
response to ultrasound IEP
Inferred from Expression Pattern
more info
PubMed 
retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
PubMed 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle hyperplasia IEA
Inferred from Electronic Annotation
more info
 
smooth muscle hyperplasia ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
caveola IEA
Inferred from Electronic Annotation
more info
 
caveola ISO
Inferred from Sequence Orthology
more info
 
cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nitric oxide synthase, endothelial
Names
EC-NOS
NOS type III
NOSIII
cNOS
constitutive NOS
endothelial NOS
endothelial nitric oxide synthase 3
nitric oxide synthase 3, endothelial cell
NP_068610.1
XP_006235934.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021838.2NP_068610.1  nitric oxide synthase, endothelial

    See identical proteins and their annotated locations for NP_068610.1

    Status: PROVISIONAL

    Source sequence(s)
    AB176831
    UniProtKB/Swiss-Prot
    Q62600
    Related
    ENSRNOP00000013058.3, ENSRNOT00000013058.4
    Conserved Domains (5) summary
    COG0369
    Location:5111158
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:67479
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:521697
    Flavodoxin_1; Flavodoxin
    pfam01698
    Location:3061
    FLO_LFY; Floricaula / Leafy protein
    cl06868
    Location:7611163
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    7321908..7342404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235872.1XP_006235934.1  nitric oxide synthase, endothelial isoform X1

    Conserved Domains (4) summary
    COG0369
    Location:4611108
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:17429
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:471647
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7111113
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    6408408..6428650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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