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Il11ra1 interleukin 11 receptor subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245983, updated on 11-Apr-2024

Summary

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Official Symbol
Il11ra1provided by RGD
Official Full Name
interleukin 11 receptor subunit alpha 1provided by RGD
Primary source
RGD:621332
See related
Ensembl:ENSRNOG00000015068 AllianceGenome:RGD:621332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable interleukin-11 binding activity and interleukin-11 receptor activity. Involved in embryo implantation. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 211.8), Uterus (RPKM 137.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61727650..61737265)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56931824..56941408)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58149150..58159072)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene uncharacterized LOC102547621 Neighboring gene C-C motif chemokine ligand 27 Neighboring gene C-C motif chemokine ligand 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells. Kiessling S, et al. J Biol Chem, 2004 Mar 12. PMID 14701802
  2. Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway. Zuo D, et al. J Stroke Cerebrovasc Dis, 2023 Feb. PMID 36521373
  3. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Nieminen P, et al. Am J Hum Genet, 2011 Jul 15. PMID 21741611, Free PMC Article
  4. Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period. Li R, et al. Reproduction, 2001 Oct. PMID 11570967
  5. Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Bilinski P, et al. Genes Dev, 1998 Jul 15. PMID 9679067, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Ralpha/STAT3 signaling pathway.
    Title: Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway.
  2. IL11RA has a role in apoptosis
    Title: Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables interleukin-11 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-11 binding ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-11 binding TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-11 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-11 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-11 receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables interleukin-11 receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein-containing complex binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within decidualization ISO
Inferred from Sequence Orthology
more info
  
involved_in developmental process ISO
Inferred from Sequence Orthology
more info
  
involved_in embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head development IEA
Inferred from Electronic Annotation
more info
  
involved_in head development ISO
Inferred from Sequence Orthology
more info
  
involved_in interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within maternal process involved in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-11 receptor subunit alpha
Names
IL-11 receptor subunit alpha
IL-11R subunit alpha
IL-11R-alpha
IL-11RA
interleukin 11 receptor, alpha chain 1
interleukin-11 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139116.1 → NP_620816.1  interleukin-11 receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_620816.1

    Status: PROVISIONAL

    Source sequence(s)
    AF347936
    UniProtKB/Swiss-Prot
    Q99MF4
    UniProtKB/TrEMBL
    A0A8I6ARG9, A6IIX5
    Related
    ENSRNOP00000020885.4, ENSRNOT00000020885.6
    Conserved Domains (3) summary
    smart00409
    Location:33 → 95
    IG; Immunoglobulin
    cd00063
    Location:218 → 310
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:111 → 202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    61727650..61737265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238023.5 → XP_006238085.1  interleukin-11 receptor subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006238085.1

    UniProtKB/Swiss-Prot
    Q99MF4
    UniProtKB/TrEMBL
    A0A8I6ARG9, A6IIX5
    Conserved Domains (3) summary
    smart00409
    Location:33 → 95
    IG; Immunoglobulin
    cd00063
    Location:218 → 310
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:111 → 202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MF4.1 GenPept UniProtKB/Swiss-Prot:Q99MF4

Gene LinkOut

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