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Nos1 nitric oxide synthase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24598, updated on 22-Sep-2022

Summary

Official Symbol
Nos1provided by RGD
Official Full Name
nitric oxide synthase 1provided by RGD
Primary source
RGD:3184
See related
Ensembl:ENSRNOG00000001130 AllianceGenome:RGD:3184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
bNOS
Summary
Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 54.3), Muscle (RPKM 48.6) and 4 other tissues See more
Orthologs
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Genomic context

See Nos1 in Genome Data Viewer
Location:
12q16
Exon count:
33
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38615111..38795492, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (44214949..44405530, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene tescalcin Neighboring gene uncharacterized LOC120095990 Neighboring gene F-box protein 21 Neighboring gene uncharacterized LOC120095991 Neighboring gene kinase suppressor of ras 2 Neighboring gene acyl-CoA-binding protein-like Neighboring gene small nucleolar RNA SNORA44

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FMN binding IDA
Inferred from Direct Assay
more info
PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadmium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase activity TAS
Traceable Author Statement
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in arginine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in behavioral response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to organic substance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hepatic stellate cell contraction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of iron ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of serotonin uptake ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitric oxide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nitric oxide mediated signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-cysteine S-nitrosylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-cysteine S-nitrosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of the force of heart contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lead ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to peptide hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in retrograde trans-synaptic signaling by nitric oxide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde trans-synaptic signaling by nitric oxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striated muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic signaling by nitric oxide ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nitric oxide synthase, brain
Names
N-NOS
NC-NOS
NOS type I
constitutive NOS
nNOS
neuronal NOS
nitric oxidase synthase
nitric oxide synthase 1, neuronal
peptidyl-cysteine S-nitrosylase NOS1
NP_434686.2
XP_038944987.1
XP_038944988.1
XP_038944989.1
XP_038944990.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052799.2NP_434686.2  nitric oxide synthase, brain

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000229
    UniProtKB/TrEMBL
    D3ZEW7
    Related
    ENSRNOP00000062735.2, ENSRNOT00000066810.4
    Conserved Domains (4) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    38615111..38795492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089060.1XP_038944988.1  nitric oxide synthase, brain isoform X1

    Conserved Domains (4) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1
  2. XM_039089059.1XP_038944987.1  nitric oxide synthase, brain isoform X1

    Conserved Domains (4) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1
  3. XM_039089061.1XP_038944989.1  nitric oxide synthase, brain isoform X1

    Conserved Domains (4) summary
    cd06202
    Location:10301433
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757964
    Flavodoxin_1
  4. XM_039089062.1XP_038944990.1  nitric oxide synthase, brain isoform X2

    Conserved Domains (4) summary
    cd06202
    Location:9961399
    Nitric_oxide_synthase; The ferredoxin-reductase (FNR) like C-terminal domain of the nitric oxide synthase (NOS) fuses with a heme-containing N-terminal oxidase domain. The reductase portion is similar in structure to NADPH dependent cytochrome-450 reductase (CYPOR), having an ...
    cd00795
    Location:300711
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    cd00992
    Location:1598
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00258
    Location:757930
    Flavodoxin_1