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Ngfr nerve growth factor receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24596, updated on 7-Sep-2023

Summary

Official Symbol
Ngfrprovided by RGD
Official Full Name
nerve growth factor receptorprovided by RGD
Primary source
RGD:3177
See related
Ensembl:ENSRNOG00000005392 AllianceGenome:RGD:3177
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16
Summary
Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TRKA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of neuron death; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; portal hypertension; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 29.6), Adrenal (RPKM 23.1) and 8 other tissues See more
Orthologs
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Genomic context

See Ngfr in Genome Data Viewer
Location:
10q26
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_06 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80515287..80533518, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83389828..83408061, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA4 Neighboring gene speckle type BTB/POZ protein Neighboring gene neurexophilin 3 Neighboring gene uncharacterized LOC120095179 Neighboring gene prohibitin 1 Neighboring gene zinc finger protein 652

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables death receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables death receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables death receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nerve growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nerve growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nerve growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables nerve growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotrophin TRKA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables neurotrophin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables preprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within detection of temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal aorta development IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal aorta development ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hair follicle development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within skin development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in clathrin-coated endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 16
Names
NGF receptor
gp80-LNGFR
low affinity nerve growth factor receptor
low affinity neurotrophin receptor p75NTR
nerve growth factor receptor (TNFR superfamily, member 16)
nerve growth factor receptor, fast
p75 ICD

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012610.2NP_036742.2  tumor necrosis factor receptor superfamily member 16 precursor

    See identical proteins and their annotated locations for NP_036742.2

    Status: VALIDATED

    Source sequence(s)
    CB725789, JACYVU010000220, X05137
    UniProtKB/Swiss-Prot
    P07174
    UniProtKB/TrEMBL
    A6HIA5, G3V6P1
    Related
    ENSRNOP00000007268.1, ENSRNOT00000007268.4
    Conserved Domains (2) summary
    cd08311
    Location:341416
    Death_p75NR; Death domain of p75 Neurotrophin Receptor
    cd13416
    Location:31189
    TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

RefSeqs of Annotated Genomes: GCF_015227675.2-RS_2023_06

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    80515287..80533518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)