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Slc25a3 solute carrier family 25 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245959, updated on 8-Mar-2025

Summary

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Official Symbol
Slc25a3provided by RGD
Official Full Name
solute carrier family 25 member 3provided by RGD
Primary source
RGD:70986
See related
EnsemblRapid:ENSRNOG00000091320 AllianceGenome:RGD:70986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Phc
Summary
Predicted to enable phosphate transmembrane transporter activity and phosphate:proton symporter activity. Predicted to be involved in phosphate ion transmembrane transport. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Mar 2025]
Expression
Biased expression in Heart (RPKM 8555.8), Muscle (RPKM 4996.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc25a3 in Genome Data Viewer
Location:
7q13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (27499164..27506685, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (25611937..25619401, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (31816601..31824064, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein Neighboring gene small nucleolar RNA, H/ACA box 53 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene thymopoietin Neighboring gene uncharacterized LOC134479859 Neighboring gene transfer RNA tryptophan (anticodon CCA) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial phosphate transport. Import of the H+/Pi symporter and role of the presequence. Pratt RD, et al. J Biol Chem, 1991 Jan 15. PMID 1985946
  2. Mitochondrial proton/phosphate transporter. An antibody directed against the COOH terminus and proteolytic cleavage experiments provides new insights about its membrane topology. Ferreira GC, et al. J Biol Chem, 1990 Dec 5. PMID 2250020
  3. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. Nishi Y, et al. Biochem J, 2011 Apr 15. PMID 21265734
  4. Energy-linked anion transport. Cloning, sequencing, and characterization of a full length cDNA encoding the rat liver mitochondrial proton/phosphate symporter. Ferreira GC, et al. J Biol Chem, 1989 Sep 15. PMID 2670944
  5. Cytoprotective regulation of the mitochondrial permeability transition pore is impaired in type 2 diabetic Goto-Kakizaki rat hearts. Itoh T, et al. J Mol Cell Cardiol, 2012 Dec. PMID 23063677

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Pi supply to mitochondria via PiC plays a critical role in ATP production and metabolism-secretion coupling in INS-1 cells.
    Title: Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphate:proton symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphate:proton symporter activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 3
Names
PTP
adenine nucleotide translocator), member 3
phosphate carrier protein, mitochondrial
phosphate transport protein
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270788.1 → NP_001257717.1  solute carrier family 25 member 3 isoform 1

    See identical proteins and their annotated locations for NP_001257717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC070918, CB577607
    UniProtKB/TrEMBL
    A0A0G2JYV5, A0A8I6GJ63, A6IFV2, Q6IRH6
    Related
    ENSRNOP00000070805.1, ENSRNOT00000080824.3
    Conserved Domains (2) summary
    PTZ00169
    Location:65 → 332
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:59 → 147
    Mito_carr; Mitochondrial carrier protein

  2. NM_139100.2 → NP_620800.2  solute carrier family 25 member 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_620800.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate in-frame exon in place of an internal exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is slightly shorter and has internal aa differences compared to isoform 1.
    Source sequence(s)
    BC070918, CB577607
    UniProtKB/TrEMBL
    A0A8I6GJ63, A6IFV1, G3V741
    Conserved Domains (2) summary
    PTZ00169
    Location:65 → 331
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:58 → 146
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    27499164..27506685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262986.1 → XP_063119056.1  solute carrier family 25 member 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GJ63

  2. XM_063262985.1 → XP_063119055.1  solute carrier family 25 member 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJ63
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16036.1 GenPept UniProtKB/Swiss-Prot:P16036

Gene LinkOut

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