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Klk1b3 kallikrein 1-related peptidase B3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24594, updated on 23-May-2018
Official Symbol
Klk1b3provided by RGD
Official Full Name
kallikrein 1-related peptidase B3provided by RGD
Primary source
RGD:3175
See related
Ensembl:ENSRNOG00000032857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Klk1; Ngfg; rK-1; Klna4; rGK-1; Klk1c1
Summary
a putative pancreatic kallikrein [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1905.4) See more
Orthologs
See Klk1b3 in Genome Data Viewer
Location:
1q22
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100199057..100203260)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (101264168..101268371)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene prostate-specific antigen-like Neighboring gene kallikrein-15-like Neighboring gene uncharacterized LOC102552731 Neighboring gene uncharacterized LOC102552485 Neighboring gene Friend virus susceptibility 1 Neighboring gene acid phosphatase 4

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Renin-angiotensin system, organism-specific biosystem (from KEGG)
    Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
  • Renin-angiotensin system, conserved biosystem (from KEGG)
    Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
kallikrein 1-related peptidase B3
Names
PS kallikrein
gamma-NGF
kallikrein 1
kallikrein a4
nerve growth factor gamma chain
nerve growth factor gamma polypeptide
pancreatic kallikrein
true tissue kallikrein
NP_113711.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031523.1NP_113711.1  kallikrein 1-related peptidase B3 precursor

    See identical proteins and their annotated locations for NP_113711.1

    Status: PROVISIONAL

    Source sequence(s)
    M11563
    UniProtKB/Swiss-Prot
    P00758
    UniProtKB/TrEMBL
    A0A0G2JSQ7
    Related
    ENSRNOP00000025831.1, ENSRNOT00000025831.2
    Conserved Domains (2) summary
    smart00020
    Location:28257
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29260
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    100199057..100203260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    88976256..88978461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. NW_001089892.1 Alternate Rn_Celera

    Range
    768..1852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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