U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DEFB113 defensin beta 113 [ Homo sapiens (human) ]

Gene ID: 245927, updated on 13-May-2022

Summary

Official Symbol
DEFB113provided by HGNC
Official Full Name
defensin beta 113provided by HGNC
Primary source
HGNC:HGNC:18094
See related
Ensembl:ENSG00000214642 AllianceGenome:HGNC:18094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEFB-13
Summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DEFB113 in Genome Data Viewer
Location:
6p12.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (49968677..49969625, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (49811571..49812519, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (49936390..49937338, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene defensin beta 133 (pseudogene) Neighboring gene defensin beta 114 Neighboring gene defensin beta 110 Neighboring gene defensin beta 112

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-defensin 113
Names
beta-defensin 13
defensin, beta 13

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037729.1NP_001032818.1  beta-defensin 113 precursor

    See identical proteins and their annotated locations for NP_001032818.1

    Status: REVIEWED

    Source sequence(s)
    DQ012017
    Consensus CDS
    CCDS43472.1
    UniProtKB/Swiss-Prot
    Q30KQ7
    Related
    ENSP00000381703.1, ENST00000398718.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    49968677..49969625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    49811571..49812519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)