U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nup58 nucleoporin 58 [ Rattus norvegicus (Norway rat) ]

Gene ID: 245922, updated on 5-Mar-2024

Summary

Official Symbol
Nup58provided by RGD
Official Full Name
nucleoporin 58provided by RGD
Primary source
RGD:631334
See related
Ensembl:ENSRNOG00000012644 AllianceGenome:RGD:631334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nup45; Nupl1; p58/p45
Summary
Enables identical protein binding activity and nuclear localization sequence binding activity. A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Located in nuclear envelope. Part of nuclear pore. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 123.7), Spleen (RPKM 106.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nup58 in Genome Data Viewer
Location:
15p12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (38534340..38583959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (34358170..34407160, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (40496754..40545933, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8A2 Neighboring gene ETS-related transcription factor Elf-2 pseudogene Neighboring gene uncharacterized LOC103693635 Neighboring gene myotubularin related protein 6 Neighboring gene APC membrane recruitment protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleoporin p58/p45
Names
58 kDa nucleoporin
nucleoporin p45
nucleoporin p58
nucleoporin-like 1
nucleoporin-like protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139091.2NP_620791.1  nucleoporin p58/p45

    See identical proteins and their annotated locations for NP_620791.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085690
    UniProtKB/Swiss-Prot
    P70581, Q9JHE1, Q9QWK7, Q9Z2W7
    UniProtKB/TrEMBL
    A0A8I6G353, A6K694, A6K695
    Related
    ENSRNOP00000084647.1, ENSRNOT00000095956.1
    Conserved Domains (2) summary
    pfam10154
    Location:230408
    DUF2362; Uncharacterized conserved protein (DUF2362)
    pfam15967
    Location:32585
    Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    38534340..38583959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092982.2XP_038948910.1  nucleoporin p58/p45 isoform X3

    UniProtKB/TrEMBL
    A6K694
    Conserved Domains (1) summary
    pfam15967
    Location:2522
    Nucleoporin_FG2; Nucleoporin FG repeated region
  2. XM_006252093.5XP_006252155.1  nucleoporin p58/p45 isoform X2

    See identical proteins and their annotated locations for XP_006252155.1

    UniProtKB/TrEMBL
    A0A8L2Q9I5, A6K693, A6K694
    Related
    ENSRNOP00000017204.6
    Conserved Domains (1) summary
    pfam15967
    Location:32539
    Nucleoporin_FG2; Nucleoporin FG repeated region
  3. XM_039092981.2XP_038948909.1  nucleoporin p58/p45 isoform X1

    UniProtKB/TrEMBL
    A6K694
    Related
    ENSRNOP00000078538.1
    Conserved Domains (1) summary
    pfam15967
    Location:2568
    Nucleoporin_FG2; Nucleoporin FG repeated region