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DEFB108B defensin beta 108B [ Homo sapiens (human) ]

Gene ID: 245911, updated on 11-Jun-2021

Summary

Official Symbol
DEFB108Bprovided by HGNC
Official Full Name
defensin beta 108Bprovided by HGNC
Primary source
HGNC:HGNC:29966
See related
Ensembl:ENSG00000184276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hBD-8; DEFB-8
Summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DEFB108B in Genome Data Viewer
Location:
11q13.4
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (71833200..71837710)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71544246..71548756)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 86 member C1, pseudogene Neighboring gene ALG1 like 9, pseudogene Neighboring gene zinc finger protein 705E, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 342 Neighboring gene defensin beta 130C (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-defensin 108B
Names
beta-defensin 8
defensin, beta 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002035.2NP_001002035.1  beta-defensin 108B precursor

    See identical proteins and their annotated locations for NP_001002035.1

    Status: VALIDATED

    Source sequence(s)
    AP002495
    Consensus CDS
    CCDS31631.1
    UniProtKB/Swiss-Prot
    Q8NET1
    Related
    ENSP00000333234.1, ENST00000328698.2
    Conserved Domains (1) summary
    pfam13841
    Location:2756
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    71833200..71837710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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