Format

Send to:

Choose Destination

DEFB107A defensin beta 107A [ Homo sapiens (human) ]

Gene ID: 245910, updated on 11-Jun-2021

Summary

Official Symbol
DEFB107Aprovided by HGNC
Official Full Name
defensin beta 107Aprovided by HGNC
Primary source
HGNC:HGNC:18086
See related
Ensembl:ENSG00000186572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BD-7; DEFB-7; DEFB107
Summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DEFB107A in Genome Data Viewer
Location:
8p23.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (7811720..7815716, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7669242..7673238, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene proline rich 23 domain containing 3, pseudogene Neighboring gene uncharacterized LOC105379216 Neighboring gene defensin beta 105A Neighboring gene defensin beta 106A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IMP
Inferred from Mutant Phenotype
more info
 
Process Evidence Code Pubs
NOT involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 
NOT involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-defensin 107
Names
beta-defensin 7
defensin, beta 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037668.1NP_001032757.2  beta-defensin 107 precursor

    See identical proteins and their annotated locations for NP_001032757.2

    Status: REVIEWED

    Source sequence(s)
    DQ119826
    Consensus CDS
    CCDS43699.1
    UniProtKB/Swiss-Prot
    Q8IZN7
    Related
    ENSP00000334681.2, ENST00000335021.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    7811720..7815716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p13 PATCHES

    Range
    710045..723507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center