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Ankrd27 ankyrin repeat domain 27 (VPS9 domain) [ Mus musculus (house mouse) ]

Gene ID: 245886, updated on 13-Aug-2022

Summary

Official Symbol
Ankrd27provided by MGI
Official Full Name
ankyrin repeat domain 27 (VPS9 domain)provided by MGI
Primary source
MGI:MGI:2444103
See related
Ensembl:ENSMUSG00000034867 AllianceGenome:MGI:2444103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Varp; D330003H11Rik
Summary
Enables SNARE binding activity and small GTPase binding activity. Involved in endosome to melanosome transport; neuron projection morphogenesis; and positive regulation of dendrite morphogenesis. Located in melanosome; neuron projection; and transport vesicle. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and stomach. Human ortholog(s) of this gene implicated in eosinophilic esophagitis. Orthologous to human ANKRD27 (ankyrin repeat domain 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 10.8), bladder adult (RPKM 7.7) and 28 other tissues See more
Orthologs
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Genomic context

See Ankrd27 in Genome Data Viewer
Location:
7; 7 B2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (35285652..35338662)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (35586226..35639237)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (36371266..36424256)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 19 Neighboring gene regulator of G-protein signalling 9 binding protein Neighboring gene programmed cell death 5 Neighboring gene predicted gene, 42379

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25907

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SNARE binding IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in tubular endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in tubular endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ankyrin repeat domain-containing protein 27
Names
VPS9 domain-containing protein
VPS9-ankyrin repeat-containing protein
VPS9-ankyrin-repeat protein
mFLJ00040 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358876.1NP_001345805.1  ankyrin repeat domain-containing protein 27 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151531
    Related
    ENSMUSP00000140259.2, ENSMUST00000190503.7
    Conserved Domains (4) summary
    cd00204
    Location:722847
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:764791
    ANK; ANK repeat [structural motif]
    cl19569
    Location:264363
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
    cl26073
    Location:559625
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_145633.3NP_663608.3  ankyrin repeat domain-containing protein 27 isoform 1

    See identical proteins and their annotated locations for NP_663608.3

    Status: VALIDATED

    Source sequence(s)
    AK144733, BC065093, BY070464, BY376293
    Consensus CDS
    CCDS21154.1
    UniProtKB/Swiss-Prot
    Q3UMR0, Q91W65
    Related
    ENSMUSP00000041751.10, ENSMUST00000040844.16
    Conserved Domains (4) summary
    cd00204
    Location:737862
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:780872
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:779806
    ANK; ANK repeat [structural motif]
    cl19569
    Location:264363
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  3. NM_178263.3NP_839994.1  ankyrin repeat domain-containing protein 27 isoform 2

    See identical proteins and their annotated locations for NP_839994.1

    Status: VALIDATED

    Source sequence(s)
    AI429389, AK085796, AK144733, BY070464
    Consensus CDS
    CCDS80706.1
    UniProtKB/Swiss-Prot
    Q3UMR0
    UniProtKB/TrEMBL
    A0A0R4J2C4
    Related
    ENSMUSP00000140554.2, ENSMUST00000186245.7
    Conserved Domains (1) summary
    cl19569
    Location:264363
    VPS9; Vacuolar sorting protein 9 (VPS9) domain

RNA

  1. NR_152519.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC151531

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    35285652..35338662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539986.3XP_006540049.1  ankyrin repeat domain-containing protein 27 isoform X1

    Conserved Domains (4) summary
    PHA02874
    Location:350570
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:742769
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:743835
    Ank_2; Ankyrin repeats (3 copies)
    cl19569
    Location:227326
    VPS9; Vacuolar sorting protein 9 (VPS9) domain
  2. XM_030242590.2XP_030098450.1  ankyrin repeat domain-containing protein 27 isoform X2

    Conserved Domains (4) summary
    PHA02874
    Location:183403
    PHA02874; ankyrin repeat protein; Provisional
    sd00045
    Location:575602
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:576668
    Ank_2; Ankyrin repeats (3 copies)
    cl19569
    Location:60159
    VPS9; Vacuolar sorting protein 9 (VPS9) domain