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Ncam1 neural cell adhesion molecule 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24586, updated on 4-Apr-2023

Summary

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Official Symbol
Ncam1provided by RGD
Official Full Name
neural cell adhesion molecule 1provided by RGD
Primary source
RGD:67378
See related
Ensembl:ENSRNOG00000031890 AllianceGenome:RGD:67378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd56; Ncam; N-CAM; NCAMC; NCAM-1; NCAM-C; N-CAM-1
Summary
Enables LRR domain binding activity and phosphatase binding activity. Involved in several processes, including axon development; positive regulation of cardiac muscle cell proliferation; and thalamus development. Located in neuronal cell body and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study middle cerebral artery infarction. Biomarker of Alzheimer's disease; congestive heart failure; hypothyroidism; mental depression; and myocardial infarction. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 216.9), Kidney (RPKM 51.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncam1 in Genome Data Viewer
Location:
8q23
Exon count:
26
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49865629..50165687, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53836797..54134881, complement)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556026 Neighboring gene uncharacterized LOC120094371 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene uncharacterized LOC120094147

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preventive Triple Gene Therapy Reduces the Negative Consequences of Ischemia-Induced Brain Injury after Modelling Stroke in a Rat. Markosyan V, et al. Int J Mol Sci, 2020 Sep 18. PMID 32962079, Free PMC Article
  2. Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis. Cheng BF, et al. Stem Cells Transl Med, 2020 Feb. PMID 31742919, Free PMC Article
  3. Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer's Disease. Voronkov DN, et al. Bull Exp Biol Med, 2019 Apr. PMID 31028587
  4. Abnormal ER quality control of neural GPI-anchored proteins via dysfunction in ER export processing in the frontal cortex of elderly subjects with schizophrenia. Kim P, et al. Transl Psychiatry, 2019 Jan 16. PMID 30664618, Free PMC Article
  5. Polysialylated Neural Cell Adhesion Molecule Supports Regeneration of Neurons in the Nucleus Ambiguus After Unilateral Recurrent Laryngeal Nerve Avulsion in Adult Rats. Ren H, et al. J Voice, 2019 Jan. PMID 29169663

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. After unilateral avulsion of the recurrent laryngeal nerve, the expression of polysialylated NCAM in the ipsilateral nucleus ambiguus was correlated with the proliferation and the differentiation of neural cells.
    Title: Polysialylated Neural Cell Adhesion Molecule Supports Regeneration of Neurons in the Nucleus Ambiguus After Unilateral Recurrent Laryngeal Nerve Avulsion in Adult Rats.
  2. A rat genetic model of vulnerability/resistance to stress-induced depression showed differential pattern of expression of BDNF, trkB, and PSA-NCAM in the hippocampus.
    Title: Effect of Acute Stress on the Expression of BDNF, trkB, and PSA-NCAM in the Hippocampus of the Roman Rats: A Genetic Model of Vulnerability/Resistance to Stress-Induced Depression.
  3. Our results strongly support the hypothesis that PSA-NCAMs play a proaggregatory role in the fasciculatory process
    Title: Axonal fasciculation and the role of polysialic acid-neural cell adhesion molecule in rat cortical neurons.
  4. CD56(140kD) up-regulation plays a pivotal role in the pathogenesis of ischemic cardiomyopathy.
    Title: The 140-kD isoform of CD56 (NCAM1) directs the molecular pathogenesis of ischemic cardiomyopathy.
  5. Stressed animals exhibited an increase in NCAM mRNA expression in the hippocampus, but not in the prefrontal cortex. The synaptosomal NCAM of the hippocampus was markedly polysialylated, while cortical PSA-NCAM was significantly decreased.
    Title: Effects of chronic social isolation on Wistar rat behavior and brain plasticity markers.
  6. A serine-to-alanine exchange at position 774 of NCAM resulted in decreased activation of the cAMP response element binding protein and decreased neurite outgrowth after NCAM stimulation in neuroblastoma cells
    Title: Phosphorylation of serine 774 of the neural cell adhesion molecule is necessary for cyclic adenosine monophosphate response element binding protein activation and neurite outgrowth.
  7. FGL triggers a long-lasting enhancement of synaptic transmission and long-term potentiation in hippocampal CA1 neurons by a facilitated synaptic delivery of AMPA receptors.
    Title: Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
  8. NCAM-derived peptide plannexin can protect immature neurons in vivo; however, in a model of status epilepticus plannexin-treated animals do not reveal any neuroprotective effects of plannexin on mature neurons.
    Title: Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus.
  9. Treatment with triiodothyronine downregulates expression of NCAM in the seminiferous tubules of rats with flutamide-induced cryptorchidism.
    Title: [The regulation of T3 on maldeveloped gonocyte (Go) and expression of NCAM in flutamide-induced cryptorchidism rat].
  10. Polysialylated-NCAM expression is important for the connectivity of interneurons in the adult cerebral cortex; its regulation may play an important role in the structural plasticity of inhibitory networks.
    Title: The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is expressed in a subpopulation of mature cortical interneurons characterized by reduced structural features and connectivity.
Submit: New GeneRIF Correction See all GeneRIFs (64)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124601

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables LRR domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cytoskeletal protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables fibroblast growth factor receptor binding TAS
Traceable Author Statement
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to inorganic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to molecule of bacterial origin IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in commissural neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in learning or memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organismal response to stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in peripheral nervous system axon regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of exocyst assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of semaphorin-plexin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to activity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cocaine IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to inorganic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lead ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thalamus development IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neural cell adhesion molecule 1
NP_113709.1
XP_006243048.1
XP_006243050.1
XP_006243056.1
XP_017450949.1
XP_017450950.1
XP_017450952.1
XP_017450953.1
XP_017450954.1
XP_038936733.1
XP_038936735.1
XP_038936736.1
XP_038936737.1
XP_038936738.1
XP_038936739.1
XP_038936740.1
XP_038936741.1
XP_038936742.1
XP_038936743.1
XP_038936744.1
XP_038936745.1
XP_038936746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395707.1 → NP_001382636.1  neural cell adhesion molecule 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198
    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:836 → 1127
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:613 → 695
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  2. NM_001395708.1 → NP_001382637.1  neural cell adhesion molecule 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198
    UniProtKB/TrEMBL
    Q3T1H3
    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 685
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  3. NM_001395709.1 → NP_001382638.1  neural cell adhesion molecule 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198

  4. NM_001395710.1 → NP_001382639.1  neural cell adhesion molecule 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198
    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 684
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  5. NM_031521.3 → NP_113709.1  neural cell adhesion molecule 1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_113709.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000198
    UniProtKB/Swiss-Prot
    P13596
    Related
    ENSRNOP00000046828.6, ENSRNOT00000047666.6
    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
    cd05865
    Location:20 → 115
    Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
    cd05869
    Location:307 → 413
    Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
    smart00408
    Location:429 → 497
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:422 → 500
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:218 → 305
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613 → 694
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    49865629..50165687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595463.2 → XP_017450952.1  neural cell adhesion molecule 1 isoform X13

    UniProtKB/TrEMBL
    F1LNY3
    Related
    ENSRNOP00000048442.5, ENSRNOT00000042281.7

  2. XM_017595461.2 → XP_017450950.1  neural cell adhesion molecule 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZLW8
    Related
    ENSRNOP00000079021.1, ENSRNOT00000113915.1

  3. XM_006242994.3 → XP_006243056.1  neural cell adhesion molecule 1 isoform X12

    UniProtKB/TrEMBL
    Q3T1H3
    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 685
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  4. XM_039080812.1 → XP_038936740.1  neural cell adhesion molecule 1 isoform X11

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:604 → 685
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  5. XM_017595460.2 → XP_017450949.1  neural cell adhesion molecule 1 isoform X7

  6. XM_006242988.3 → XP_006243050.1  neural cell adhesion molecule 1 isoform X6

    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:836 → 1127
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:613 → 695
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  7. XM_039080811.1 → XP_038936739.1  neural cell adhesion molecule 1 isoform X10

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:614 → 695
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  8. XM_039080809.1 → XP_038936737.1  neural cell adhesion molecule 1 isoform X5

    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:837 → 1128
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:614 → 696
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  9. XM_039080808.1 → XP_038936736.1  neural cell adhesion molecule 1 isoform X4

    Related
    ENSRNOP00000071509.1, ENSRNOT00000082257.2
    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:840 → 1131
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:618 → 699
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  10. XM_006242986.3 → XP_006243048.1  neural cell adhesion molecule 1 isoform X3

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    Ig3_NCAM-1_like; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
    cd05865
    Location:20 → 115
    Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
    cd05869
    Location:307 → 413
    Ig5_NCAM-1; Fifth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
    smart00408
    Location:429 → 497
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:422 → 500
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:218 → 305
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:618 → 700
    fn3; Fibronectin type III domain

  11. XM_039080810.1 → XP_038936738.1  neural cell adhesion molecule 1 isoform X9

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:649 → 731
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  12. XM_039080807.1 → XP_038936735.1  neural cell adhesion molecule 1 isoform X2

    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:841 → 1132
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:619 → 700
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  13. XM_039080805.1 → XP_038936733.1  neural cell adhesion molecule 1 isoform X1

    Conserved Domains (9) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam05109
    Location:842 → 1133
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00041
    Location:619 → 701
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  14. XM_017595465.2 → XP_017450954.1  neural cell adhesion molecule 1 isoform X20

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 684
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  15. XM_039080817.1 → XP_038936745.1  neural cell adhesion molecule 1 isoform X19

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 685
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  16. XM_039080816.1 → XP_038936744.1  neural cell adhesion molecule 1 isoform X18

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:604 → 685
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  17. XM_039080818.1 → XP_038936746.1  neural cell adhesion molecule 1 isoform X21

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 403
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:499 → 596
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:639 → 720
    fn3; Fibronectin type III domain
    pfam13927
    Location:412 → 484
    Ig_3; Immunoglobulin domain
    cd00096
    Location:423 → 427
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  18. XM_039080815.1 → XP_038936743.1  neural cell adhesion molecule 1 isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZQ32
    Related
    ENSRNOP00000080203.1, ENSRNOT00000099284.1
    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:613 → 694
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  19. XM_039080814.1 → XP_038936742.1  neural cell adhesion molecule 1 isoform X16

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:618 → 699
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains

  20. XM_017595464.2 → XP_017450953.1  neural cell adhesion molecule 1 isoform X15

  21. XM_039080813.1 → XP_038936741.1  neural cell adhesion molecule 1 isoform X14

    Conserved Domains (8) summary
    cd05730
    Location:211 → 308
    IgI_3_NCAM-1; Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains
    cd05869
    Location:307 → 413
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:509 → 606
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:649 → 731
    fn3; Fibronectin type III domain
    pfam13927
    Location:422 → 494
    Ig_3; Immunoglobulin domain
    cd00096
    Location:433 → 437
    Ig; Ig strand B [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13596.1 GenPept UniProtKB/Swiss-Prot:P13596

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