U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Polr2h polymerase (RNA) II (DNA directed) polypeptide H [ Mus musculus (house mouse) ]

Gene ID: 245841, updated on 4-Mar-2023

Summary

Official Symbol
Polr2hprovided by MGI
Official Full Name
polymerase (RNA) II (DNA directed) polypeptide Hprovided by MGI
Primary source
MGI:MGI:2384309
See related
Ensembl:ENSMUSG00000021018 AllianceGenome:MGI:2384309
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.5), limb E14.5 (RPKM 12.7) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Polr2h in Genome Data Viewer
Location:
16; 16 B1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20536576..20541022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20717826..20722272)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene thrombopoietin Neighboring gene chordin Neighboring gene predicted gene, 22741

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8248, MGC103049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to RNA polymerase II activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerases I, II, and III subunit RPABC3
Names
DNA-directed RNA polymerase II subunit H
RNA polymerases I, II, and III subunit ABC3
RPB17
RPB8 homolog
NP_001343352.1
NP_663607.1
XP_030104975.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356423.2NP_001343352.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT010490
    Related
    ENSMUSP00000155920.2, ENSMUST00000161038.2
    Conserved Domains (1) summary
    smart00658
    Location:1111
    RPOL8c; RNA polymerase subunit 8
  2. NM_001417237.1NP_001404166.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT010490
  3. NM_001417238.1NP_001404167.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT010490
  4. NM_145632.3NP_663607.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform 1

    See identical proteins and their annotated locations for NP_663607.1

    Status: VALIDATED

    Source sequence(s)
    CT010490
    Consensus CDS
    CCDS28058.1
    UniProtKB/Swiss-Prot
    Q3TT30, Q923G2
    UniProtKB/TrEMBL
    A0A6P5R8C0
    Related
    ENSMUSP00000021405.8, ENSMUST00000021405.8
    Conserved Domains (1) summary
    smart00658
    Location:2147
    RPOL8c; RNA polymerase subunit 8

RNA

  1. NR_184434.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010490
  2. NR_184435.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT010490

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    20536576..20541022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249115.2XP_030104975.1  DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1

    UniProtKB/TrEMBL
    A0A338P6I2, A0A8C6GN84
    Related
    ENSMUSP00000155967.2, ENSMUST00000231392.2
    Conserved Domains (1) summary
    pfam03870
    Location:18140
    RNA_pol_Rpb8; RNA polymerase Rpb8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_184436.1: Suppressed sequence

    Description
    NR_184436.1: This RefSeq was removed because currently there is insufficient support for the transcript.