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MS4A6E membrane spanning 4-domains A6E [ Homo sapiens (human) ]

Gene ID: 245802, updated on 25-Jan-2022

Summary

Official Symbol
MS4A6Eprovided by HGNC
Official Full Name
membrane spanning 4-domains A6Eprovided by HGNC
Primary source
HGNC:HGNC:14285
See related
Ensembl:ENSG00000166926 MIM:608402; AllianceGenome:HGNC:14285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 32.3) See more
Orthologs
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Genomic context

See MS4A6E in Genome Data Viewer
Location:
11q12.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60327255..60349072)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60094728..60116545)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A4E Neighboring gene microRNA 6503 Neighboring gene membrane spanning 4-domains A4A Neighboring gene Sharpr-MPRA regulatory region 5454 Neighboring gene membrane spanning 4-domains A7 Neighboring gene membrane spanning 4-domains A14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of membrane-spanning 4-domains, subfamily A, member 6E (MS4A6E) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126832

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 6E
Names
membrane-spanning 4-domains, subfamily A, member 6E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139249.4NP_640342.1  membrane-spanning 4-domains subfamily A member 6E

    See identical proteins and their annotated locations for NP_640342.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AP003127
    Consensus CDS
    CCDS7984.1
    UniProtKB/Swiss-Prot
    Q96DS6
    Related
    ENSP00000507799.1, ENST00000684409.1
    Conserved Domains (1) summary
    pfam04103
    Location:50143
    CD20; CD20-like family

RNA

  1. NR_170614.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003127
  2. NR_170615.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003127
  3. NR_170616.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP003127

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60327255..60349072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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