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Myc MYC proto-oncogene, bHLH transcription factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24577, updated on 22-Nov-2020

Summary

Official Symbol
Mycprovided by RGD
Official Full Name
MYC proto-oncogene, bHLH transcription factorprovided by RGD
Primary source
RGD:3130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mMyc; c-myc; RNCMYC
Summary
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma, in human. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini, in human and mouse. Rat mRNA also has a similarly placed CUG upstream of the AUG start site, suggesting that it may also produce two Myc proteins. [provided by RefSeq, Jul 2008]
Annotation information
Annotation category: suggests misassembly
Expression
Biased expression in Spleen (RPKM 98.0), Thymus (RPKM 64.5) and 9 other tissues See more
Orthologs

Genomic context

See Myc in Genome Data Viewer
Location:
7q33
Exon count:
3
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (102586313..102591240)
106 current Rn_Celera (GCF_000002265.2) 7 AC_000075.1 (90263903..90268823)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (103157452..103162379)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547563 Neighboring gene alpha-1-B glycoprotein Neighboring gene uncharacterized LOC108351503 Neighboring gene Pvt1 oncogene Neighboring gene uncharacterized LOC103692926 Neighboring gene uncharacterized LOC102547802

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105490

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
E-box binding ISO
Inferred from Sequence Orthology
more info
 
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic initiation factor eIF2 binding ISO
Inferred from Sequence Orthology
more info
 
mRNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
repressing transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
DNA-templated transcription, initiation IDA
Inferred from Direct Assay
more info
PubMed 
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
G0 to G1 transition IEP
Inferred from Expression Pattern
more info
PubMed 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
amino acid transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
branching involved in ureteric bud morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway involved in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
cellular response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to arsenite(3-) IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to carbohydrate stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to cycloheximide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to dimethyl sulfoxide IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to endothelin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to epidermal growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to estrogen stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to fibroblast growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to growth hormone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hydrostatic pressure IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lectin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to phorbol 13-acetate 12-myristate IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to platelet-derived growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to prolactin IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to putrescine IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to testosterone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
chromosome organization ISO
Inferred from Sequence Orthology
more info
 
chromosome organization ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of mechanical stimulus involved in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
flavonoid metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
fungal-type cell wall polysaccharide metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypothalamus development IEP
Inferred from Expression Pattern
more info
PubMed 
in utero embryonic development IEP
Inferred from Expression Pattern
more info
PubMed 
inner mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
lactic acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell division ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of monocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development IEP
Inferred from Expression Pattern
more info
PubMed 
ovulation IEP
Inferred from Expression Pattern
more info
PubMed 
pathogenesis TAS
Traceable Author Statement
more info
PubMed 
pigmentation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metanephric cap mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric cap mesenchymal cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription initiation from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex disassembly ISO
Inferred from Sequence Orthology
more info
 
pyruvate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
re-entry into mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
regulation of somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
regulation of telomere maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to alkaloid ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to human chorionic gonadotropin IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation ISO
Inferred from Sequence Orthology
more info
 
response to wounding IEP
Inferred from Expression Pattern
more info
PubMed 
skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
 
transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transformation of host cell by virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
euchromatin ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myc proto-oncogene protein
Names
Avian myelocytomatosis viral (v-myc) oncogene homolog
myelocytomatosis oncogene
myelocytomatosis viral oncogene homolog
proto-oncogene c-Myc
transcription factor p64
v-myc avian myelocytomatosis viral oncogene homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012603.2NP_036735.2  myc proto-oncogene protein

    See identical proteins and their annotated locations for NP_036735.2

    Status: REVIEWED

    Source sequence(s)
    AY679730
    UniProtKB/Swiss-Prot
    P09416
    Conserved Domains (3) summary
    cd00083
    Location:366425
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam01056
    Location:20359
    Myc_N; Myc amino-terminal region
    pfam02344
    Location:422451
    Myc-LZ; Myc leucine zipper domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    102586313..102591240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    90263903..90268823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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