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Gucy2g guanylate cyclase 2G [ Rattus norvegicus (Norway rat) ]

Gene ID: 245708, updated on 9-Dec-2024

Summary

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Official Symbol
Gucy2gprovided by RGD
Official Full Name
guanylate cyclase 2Gprovided by RGD
Primary source
RGD:621853
See related
EnsemblRapid:ENSRNOG00000015724 AllianceGenome:RGD:621853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ksGC
Summary
Predicted to enable guanylate cyclase activity and peptide receptor activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Predicted to be located in cytoplasm and external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 13.9), Kidney (RPKM 5.8) and 1 other tissue See more
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Genomic context

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See Gucy2g in Genome Data Viewer
Location:
1q55
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (264241830..264285615, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (254237778..254280277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (276187243..276228574, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553657 Neighboring gene extensin-like Neighboring gene glycerol-3-phosphate acyltransferase, mitochondrial Neighboring gene tectorin beta Neighboring gene acyl-CoA synthetase long-chain family member 5 Neighboring gene zinc finger DHHC-type palmitoyltransferase 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC134485256

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression. Kojima M, et al. Biochem Biophys Res Commun, 1995 Dec 26. PMID 8554626
  2. The cloning and expression of a new guanylyl cyclase orphan receptor. Schulz S, et al. J Biol Chem, 1998 Jan 9. PMID 9422765
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity TAS
Traceable Author Statement
more info
 PubMed 
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate cyclase 2G
Names
GC-G
guanylyl cyclase receptor G
guanylyl cyclase with kinase-like domain, soluble
kinase-like domain-containing soluble guanylyl cyclase
NP_620611.2
XP_038953385.1
XP_038953425.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139042.2 → NP_620611.2  guanylate cyclase 2G

    See identical proteins and their annotated locations for NP_620611.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O54884, P55205
    UniProtKB/TrEMBL
    A6JHY5, F1MA14
    Related
    ENSRNOP00000021744.4, ENSRNOT00000021746.7
    Conserved Domains (5) summary
    cd06372
    Location:50 → 439
    PBP1_GC_G_like; Ligand-binding domain of membrane guanylyl cyclase G
    smart00044
    Location:868 → 1058
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd13992
    Location:558 → 832
    PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors
    pfam00211
    Location:895 → 1081
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam01094
    Location:66 → 417
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    264241830..264285615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097457.2 → XP_038953385.1  guanylate cyclase 2G isoform X1

    UniProtKB/TrEMBL
    A6JHY7
    Conserved Domains (2) summary
    smart00044
    Location:199 → 389
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:1 → 163
    PKc_like; Protein Kinases, catalytic domain

  2. XM_039097497.2 → XP_038953425.1  guanylate cyclase 2G isoform X1

    UniProtKB/TrEMBL
    A6JHY7
    Conserved Domains (2) summary
    smart00044
    Location:199 → 389
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cl21453
    Location:1 → 163
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55205.2 GenPept UniProtKB/Swiss-Prot:P55205

Gene LinkOut

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