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igf1rb insulin-like growth factor 1b receptor [ Danio rerio (zebrafish) ]

Gene ID: 245702, updated on 8-Aug-2021

Summary

Official Symbol
igf1rbprovided by ZNC
Official Full Name
insulin-like growth factor 1b receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-020503-2
See related
Ensembl:ENSDARG00000034434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
IGF; IGF-; IGF-IR; IGF-IRb; wu:fb03h06
Orthologs
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Genomic context

See igf1rb in Genome Data Viewer
Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (15447177..15603094)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (15198890..15354807)
103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (16216011..16371928)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene si:ch211-276a23.5 Neighboring gene si:ch211-106j24.1 Neighboring gene leucine rich repeat containing 28 Neighboring gene myocyte enhancer factor 2ab

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
enables insulin receptor substrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin receptor substrate binding IEA
Inferred from Electronic Annotation
more info
 
enables insulin-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chordate embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic camera-type eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within semicircular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of insulin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
insulin-like growth factor 1b receptor
NP_694501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152969.1NP_694501.1  insulin-like growth factor 1b receptor precursor

    See identical proteins and their annotated locations for NP_694501.1

    Status: PROVISIONAL

    Source sequence(s)
    AF400276
    Related
    ENSDARP00000046541.4, ENSDART00000046542.7
    Conserved Domains (6) summary
    cd05032
    Location:9801255
    PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases
    cd00063
    Location:823910
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00064
    Location:219265
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam00757
    Location:176320
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:338449
    Recep_L_domain; Receptor L domain
    pfam07714
    Location:9871253
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    15447177..15603094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394679.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    10947..154302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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