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Mst1 macrophage stimulating 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24566, updated on 18-Apr-2019

Summary

Official Symbol
Mst1provided by RGD
Official Full Name
macrophage stimulating 1provided by RGD
Primary source
RGD:3114
See related
Ensembl:ENSRNOG00000019680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
E2F2
Summary
ligand for receptor tyrosine kinase STK/RON; may mediate germ cell-germ cell interaction during spermatogenesis, and acquisition of sperm motility and/or fertilizing capacity in the epididymis [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 716.5), Adrenal (RPKM 80.4) and 2 other tissues See more
Orthologs

Genomic context

See Mst1 in Genome Data Viewer
Location:
8q32
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116857716..116862286)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (116211755..116216379)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene inositol hexakisphosphate kinase 1 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon (presynaptic cytomatrix protein)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
embryo implantation ISO
Inferred from Sequence Orthology
more info
PubMed 
flagellated sperm motility IEP
Inferred from Expression Pattern
more info
PubMed 
mammary duct terminal end bud growth IEA
Inferred from Electronic Annotation
more info
 
mammary duct terminal end bud growth ISO
Inferred from Sequence Orthology
more info
PubMed 
mammary gland development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of macrophage chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
vacuole IEA
Inferred from Electronic Annotation
more info
 
vacuole ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor-like protein
Names
D8h3f15s2
E2F transcription factor 2
Macrophage stimulating 1 (hepatocyte growth factor-like)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024352.1NP_077328.1  hepatocyte growth factor-like protein precursor

    See identical proteins and their annotated locations for NP_077328.1

    Status: PROVISIONAL

    Source sequence(s)
    X95096
    UniProtKB/TrEMBL
    P70521
    Related
    ENSRNOP00000026711.5, ENSRNOT00000026711.7
    Conserved Domains (4) summary
    smart00020
    Location:488709
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:377459
    KR; Kringle domain
    cd00190
    Location:489712
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00024
    Location:25103
    PAN_1; PAN domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    116857716..116862286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    108073056..108077626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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