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Mpg N-methylpurine-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24561, updated on 21-Jul-2018

Summary

Official Symbol
Mpgprovided by RGD
Official Full Name
N-methylpurine-DNA glycosylaseprovided by RGD
Primary source
RGD:3106
See related
Ensembl:ENSRNOG00000020571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
enzyme that cleaves 3-methyladenine and 7-methylguanine residues from DNA [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 44.9), Spleen (RPKM 43.3) and 9 other tissues See more
Orthologs

Genomic context

See Mpg in Genome Data Viewer
Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15661768..15667995, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (15556911..15563138, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene hemoglobin subunit zeta Neighboring gene NPR3-like, GATOR1 complex subunit Neighboring gene rhomboid 5 homolog 1 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-3-methyladenine glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-3-methylguanine glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-7-methyladenine glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
DNA-7-methylguanine glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
alkylbase DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alkylbase DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
 
alkylbase DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
base-excision repair IEA
Inferred from Electronic Annotation
more info
 
base-excision repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-3-methyladenine glycosylase
Names
3-alkyladenine DNA glycosylase
3-methyladenine DNA glycosidase
ADPG
N-methylpurine-DNA glycocylase
NP_036733.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012601.2NP_036733.2  DNA-3-methyladenine glycosylase

    See identical proteins and their annotated locations for NP_036733.2

    Status: VALIDATED

    Source sequence(s)
    AA899760, AC096051, AW435341, CB765983
    UniProtKB/TrEMBL
    D3ZEM0
    Related
    ENSRNOP00000027940.3, ENSRNOT00000027940.4
    Conserved Domains (1) summary
    TIGR00567
    Location:105305
    3mg; DNA-3-methyladenine glycosylase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    15661768..15667995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    15063825..15070052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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