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Mpg N-methylpurine-DNA glycosylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 24561, updated on 6-Jul-2026
Official Symbol
Mpgprovided by RGD
Official Full Name
N-methylpurine-DNA glycosylaseprovided by RGD
Primary source
RGD:3106
See related
Ensembl:ENSRNOG00000020571 AllianceGenome:RGD:3106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and alkylbase DNA N-glycosylase activity. Predicted to be involved in base-excision repair. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Orthologous to human MPG (N-methylpurine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Kidney (RPKM 44.9), Spleen (RPKM 43.3) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Mpg in Genome Data Viewer
Location:
10q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15900697..15906981, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15396246..15402528, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hemoglobin subunit zeta Neighboring gene NPR3-like, GATOR1 complex subunit Neighboring gene rhomboid 5 homolog 1 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 25

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Isolation and structure of a cDNA expressing a mammalian 3-methyladenine-DNA glycosylase. O'Connor TR, et al. EMBO J, 1990 Oct. PMID 1698614, Free PMC Article
  2. New immunoaffinity-LC-MS/MS methodology reveals that Aag null mice are deficient in their ability to clear 1,N6-etheno-deoxyadenosine DNA lesions from lung and liver in vivo. Ham AJ, et al. DNA Repair (Amst), 2004 Mar 4. PMID 15177041
  3. Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1,N6-ethenoadenine and hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine. Hang B, et al. Proc Natl Acad Sci U S A, 1997 Nov 25. PMID 9371767, Free PMC Article
  4. Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11. Engelward BP, et al. Carcinogenesis, 1993 Feb. PMID 8435858
  5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables alkylbase DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkylbase DNA N-glycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables alkylbase DNA N-glycosylase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in base-excision repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within base-excision repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-3-methyladenine glycosylase
Names
3-alkyladenine DNA glycosylase
3-methyladenine DNA glycosidase
ADPG
N-methylpurine-DNA glycocylase
NP_036733.2
XP_038941119.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429907.1 → NP_001416836.1  DNA-3-methyladenine glycosylase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  2. NM_012601.3 → NP_036733.2  DNA-3-methyladenine glycosylase isoform 1

    See identical proteins and their annotated locations for NP_036733.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P23571
    UniProtKB/TrEMBL
    A0A0G2K6B9
    Related
    ENSRNOP00000073752.3, ENSRNOT00000085746.3
    Conserved Domains (1) summary
    TIGR00567
    Location:105 → 305
    3mg; DNA-3-methyladenine glycosylase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15900697..15906981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085191.2 → XP_038941119.1  DNA-3-methyladenine glycosylase isoform X1

    Conserved Domains (1) summary
    cl14785
    Location:109 → 192
    FMT_C_like; Carboxy-terminal domain of Formyltransferase and similar domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23571.2 GenPept UniProtKB/Swiss-Prot:P23571

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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