U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nlgn3 neuroligin 3 [ Mus musculus (house mouse) ]

Gene ID: 245537, updated on 5-Jan-2023

Summary

Official Symbol
Nlgn3provided by MGI
Official Full Name
neuroligin 3provided by MGI
Primary source
MGI:MGI:2444609
See related
Ensembl:ENSMUSG00000031302 AllianceGenome:MGI:2444609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NL3; HNL3; NLG3; A230085M13Rik
Summary
Predicted to enable several functions, including cell adhesion molecule binding activity; neurexin family protein binding activity; and scaffold protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of neurotransmitter receptor activity; and regulation of synapse organization. Acts upstream of or within several processes, including oligodendrocyte differentiation; regulation of respiratory gaseous exchange by nervous system process; and visual learning. Predicted to be located in endocytic vesicle; excitatory synapse; and neuronal cell body. Predicted to be integral component of postsynaptic membrane. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Predicted to colocalize with dendrite and inhibitory synapse. Is expressed in several structures, including central nervous system; eye; and heart. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 20.3), CNS E18 (RPKM 19.2) and 11 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nlgn3 in Genome Data Viewer
Location:
X; X D
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100342785..100364956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101299179..101321350)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 2 receptor, gamma chain Neighboring gene mediator complex subunit 12 Neighboring gene predicted gene, 31385 Neighboring gene gap junction protein, beta 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (10)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Med12

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adult behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in axon extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian sleep/wake cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within modulation of chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inhibitory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to synapse ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic vesicle clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in postsynaptic membrane assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic specialization assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in prepulse inhibition ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in presynaptic membrane assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of terminal button organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhythmic synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within synapse organization ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vocalization behavior ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in excitatory synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in inhibitory synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
neuroligin-3
Names
gliotactin homolog
neuroligin 3 protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172932.4NP_766520.2  neuroligin-3 precursor

    See identical proteins and their annotated locations for NP_766520.2

    Status: VALIDATED

    Source sequence(s)
    AK039018, BB619023, BI134434, CF898143
    Consensus CDS
    CCDS30313.1
    UniProtKB/Swiss-Prot
    Q8BXR4, Q8BYM5
    UniProtKB/TrEMBL
    A0A5S9EF37, A0A6P5P402, A0A8C6IHW0
    Related
    ENSMUSP00000066304.3, ENSMUST00000065858.3
    Conserved Domains (1) summary
    pfam00135
    Location:39601
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100342785..100364956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)