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Zc4h2 zinc finger, C4H2 domain containing [ Mus musculus (house mouse) ]

Gene ID: 245522, updated on 5-Mar-2024

Summary

Official Symbol
Zc4h2provided by MGI
Official Full Name
zinc finger, C4H2 domain containingprovided by MGI
Primary source
MGI:MGI:2679294
See related
Ensembl:ENSMUSG00000035062 AllianceGenome:MGI:2679294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm372; mKIAA1166
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including noradrenergic neuron development; positive regulation of DNA-binding transcription factor activity; and protein monoubiquitination. Located in neuronal cell body. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 17.7), CNS E14 (RPKM 16.9) and 9 other tissues See more
Orthologs
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Genomic context

See Zc4h2 in Genome Data Viewer
Location:
X C3; X 41.99 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94682793..94702115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95639187..95658509, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ring finger and WD repeat domain 2 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 12 Neighboring gene STARR-seq mESC enhancer starr_47573 Neighboring gene STARR-seq mESC enhancer starr_47574 Neighboring gene adenylosuccinate lyase pseudogene Neighboring gene predicted gene, 29889

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1166, MGC105164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger C4H2 domain-containing protein
Names
hepatocellular carcinoma-associated antigen 127 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003916.2NP_001003916.1  zinc finger C4H2 domain-containing protein isoform 1

    See identical proteins and their annotated locations for NP_001003916.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI844550, BC079862, BY200912
    Consensus CDS
    CCDS30284.1
    UniProtKB/Swiss-Prot
    B1AUU6, Q3TSJ9, Q3U274, Q504M3, Q68FG0, Q6ZPW6
    Related
    ENSMUSP00000041236.7, ENSMUST00000044382.7
    Conserved Domains (1) summary
    pfam10146
    Location:13221
    zf-C4H2; Zinc finger-containing protein
  2. NM_001289696.1NP_001276625.1  zinc finger C4H2 domain-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001276625.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter isoform (2) that has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI844550, AL671982, BC079862, BY200912
    Consensus CDS
    CCDS81154.1
    UniProtKB/TrEMBL
    Q05BE0
    Related
    ENSMUSP00000112449.2, ENSMUST00000120620.8
    Conserved Domains (1) summary
    pfam10146
    Location:13130
    zf-C4H2; Zinc finger-containing protein
  3. NM_001289697.1NP_001276626.1  zinc finger C4H2 domain-containing protein isoform 3

    See identical proteins and their annotated locations for NP_001276626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 3.
    Source sequence(s)
    AI844550, BC079862, BY200912
    Consensus CDS
    CCDS81153.1
    UniProtKB/Swiss-Prot
    Q68FG0
    Related
    ENSMUSP00000113689.2, ENSMUST00000119640.8
    Conserved Domains (1) summary
    pfam10146
    Location:13214
    zf-C4H2; Zinc finger-containing protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    94682793..94702115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247587.4XP_011245889.1  zinc finger C4H2 domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011245889.1

    Conserved Domains (1) summary
    pfam10146
    Location:17224
    zf-C4H2; Zinc finger-containing protein