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Me1 malic enzyme 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24552, updated on 5-Aug-2018

Summary

Official Symbol
Me1provided by RGD
Official Full Name
malic enzyme 1provided by RGD
Primary source
RGD:3074
See related
Ensembl:ENSRNOG00000009715
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MOD1
Summary
catalyzes the NADP+ dependent conversion of S-malate to pyruvate [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 685.9), Muscle (RPKM 322.4) and 7 other tissues See more
Orthologs

Genomic context

See Me1 in Genome Data Viewer
Location:
8q31
Exon count:
15
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (94256830..94368834, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (93769078..93863611, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 3 Neighboring gene RWD domain containing 2A Neighboring gene serine protease 35 Neighboring gene synaptosome associated protein 91

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NAD binding IEA
Inferred from Electronic Annotation
more info
 
NADP binding IDA
Inferred from Direct Assay
more info
PubMed 
malate dehydrogenase (decarboxylating) (NAD+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
malate dehydrogenase (decarboxylating) (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
malate dehydrogenase (decarboxylating) (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
malic enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malic enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
malic enzyme activity ISO
Inferred from Sequence Orthology
more info
 
malic enzyme activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
malate metabolic process IEA
Inferred from Electronic Annotation
more info
 
malate metabolic process ISO
Inferred from Sequence Orthology
more info
 
malate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of NADP metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
response to hormone IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NADP-dependent malic enzyme
Names
NADP-ME
cytosolic malic enzyme 1
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
malic enzyme 1, NADP(+)-dependent, cytosolic
malic enzyme 1, soluble
NP_036732.2
XP_008764661.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012600.2NP_036732.2  NADP-dependent malic enzyme

    Status: VALIDATED

    Source sequence(s)
    AABR03062333, AABR03064582, AABR03064643, CB613492, CB810743, CO395247, CO560778, H34871
    Related
    ENSRNOP00000013244.6, ENSRNOT00000013244.6
    Conserved Domains (3) summary
    cd05312
    Location:270547
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:3551
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:79260
    malic; Malic enzyme, N-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    94256830..94368834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766439.2XP_008764661.1  NADP-dependent malic enzyme isoform X1

    Conserved Domains (3) summary
    cd05312
    Location:245522
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:2526
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:54235
    malic; Malic enzyme, N-terminal domain

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    87151761..87246579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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