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Mbp myelin basic protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24547, updated on 4-Apr-2023

Summary

Official Symbol
Mbpprovided by RGD
Official Full Name
myelin basic proteinprovided by RGD
Primary source
RGD:3054
See related
Ensembl:ENSRNOG00000016516 AllianceGenome:RGD:3054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mbps
Summary
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 4946.1) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mbp in Genome Data Viewer
Location:
18q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (75855878..75966404)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (79326738..79437310)

Chromosome 18 - NC_051353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548977 Neighboring gene galanin receptor 1 Neighboring gene uncharacterized LOC120098219 Neighboring gene uncharacterized LOC108348833 Neighboring gene zinc finger protein 236 Neighboring gene uncharacterized LOC120098255

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of myelin sheath IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural constituent of myelin sheath TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within membrane organization ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to fatty acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mercury ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in substantia nigra development ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in compact myelin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in compact myelin IDA
Inferred from Direct Assay
more info
PubMed 
located_in compact myelin ISO
Inferred from Sequence Orthology
more info
 
is_active_in internode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in internode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myelin basic protein; Golli-Mbp
Names
MBP S
myelin basic protein Golli-mbp
myelin basic protein S

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025289.1NP_001020460.1  Golli-Mbp isoform 1

    See identical proteins and their annotated locations for NP_001020460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes Golli-mbp isoform 1.
    Source sequence(s)
    BC084713
    UniProtKB/TrEMBL
    Q5XFW1
    Related
    ENSRNOP00000070157.2, ENSRNOT00000089879.2
    Conserved Domains (1) summary
    pfam01669
    Location:149195
    Myelin_MBP; Myelin basic protein
  2. NM_001025291.1NP_001020462.1  myelin basic protein isoform 1

    See identical proteins and their annotated locations for NP_001020462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
    Source sequence(s)
    AF439750, AI145512, AJ132898, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688, Q9Z1J6
    UniProtKB/TrEMBL
    I7FKL4
    Conserved Domains (1) summary
    pfam01669
    Location:16194
    Myelin_MBP; Myelin basic protein
  3. NM_001025292.1NP_001020463.1  myelin basic protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 26 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, AJ132897, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Conserved Domains (1) summary
    pfam01669
    Location:16168
    Myelin_MBP; Myelin basic protein
  4. NM_001025293.1NP_001020464.1  myelin basic protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, AJ132896, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Conserved Domains (1) summary
    pfam01669
    Location:16148
    Myelin_MBP; Myelin basic protein
  5. NM_001025294.1NP_001020465.1  myelin basic protein isoform 4

    See identical proteins and their annotated locations for NP_001020465.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Conserved Domains (1) summary
    pfam01669
    Location:16157
    Myelin_MBP; Myelin basic protein
  6. NM_017026.2NP_058722.1  myelin basic protein isoform 5

    See identical proteins and their annotated locations for NP_058722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AI145512, BC094522, CB586909
    UniProtKB/Swiss-Prot
    P02688
    Conserved Domains (1) summary
    pfam01669
    Location:16122
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051353.1 Reference mRatBN7.2 Primary Assembly

    Range
    75855878..75966404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254997.4XP_006255059.1  myelin basic protein isoform X3

    See identical proteins and their annotated locations for XP_006255059.1

    UniProtKB/TrEMBL
    A0A8L2QCF0
    Related
    ENSRNOP00000022303.5, ENSRNOT00000022303.8
    Conserved Domains (1) summary
    pfam01669
    Location:149328
    Myelin_MBP; Myelin basic protein
  2. XM_039096569.1XP_038952497.1  myelin basic protein isoform X3

    UniProtKB/TrEMBL
    A0A8L2QCF0
    Conserved Domains (1) summary
    pfam01669
    Location:149328
    Myelin_MBP; Myelin basic protein
  3. XM_039096568.1XP_038952496.1  Golli-Mbp isoform X1

    Conserved Domains (1) summary
    pfam01669
    Location:149317
    Myelin_MBP; Myelin basic protein
  4. XM_017600847.1XP_017456336.1  Golli-Mbp isoform X6

  5. XM_017600846.2XP_017456335.1  Golli-Mbp isoform X5

    UniProtKB/TrEMBL
    A0A8L2QCS8
    Related
    ENSRNOP00000022280.6, ENSRNOT00000022280.6
    Conserved Domains (1) summary
    pfam01669
    Location:149281
    Myelin_MBP; Myelin basic protein
  6. XM_039096570.1XP_038952498.1  Golli-Mbp isoform X4

    UniProtKB/TrEMBL
    A0A8L2QRV9
    Related
    ENSRNOP00000055098.4, ENSRNOT00000058296.6
    Conserved Domains (1) summary
    pfam01669
    Location:149291
    Myelin_MBP; Myelin basic protein
  7. XM_017600845.2XP_017456334.1  Golli-Mbp isoform X2

    UniProtKB/TrEMBL
    A0A8L2UMS1
    Related
    ENSRNOP00000055097.4, ENSRNOT00000058295.6
  8. XM_017600849.2XP_017456338.1  Golli-Mbp isoform X9

    UniProtKB/TrEMBL
    A0A8I6A591
    Related
    ENSRNOP00000086141.1, ENSRNOT00000107098.1
    Conserved Domains (1) summary
    pfam01669
    Location:149249
    Myelin_MBP; Myelin basic protein
  9. XM_017600848.2XP_017456337.1  Golli-Mbp isoform X7

  10. XM_039096571.1XP_038952499.1  myelin basic protein isoform X8

    Conserved Domains (1) summary
    pfam01669
    Location:114293
    Myelin_MBP; Myelin basic protein