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Mbp myelin basic protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24547, updated on 3-Jun-2018
Official Symbol
Mbpprovided by RGD
Official Full Name
myelin basic proteinprovided by RGD
Primary source
RGD:3054
See related
Ensembl:ENSRNOG00000016516
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mbps
Summary
The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long Mbp gene (otherwise called "Golli-Mbp") that contains 3 additional exons located upstream of the classic Mbp exons. Alternative splicing from the Golli and the Mbp transcription start sites gives rise to 2 sets of Mbp-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-Mbp, spliced in-frame to 1 or more Mbp exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to Mbp aa sequence. The second family of transcripts contain only Mbp exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the Mbp transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. Mutation of the Mbp gene is associated with the 'shiverer' and 'myelin deficient' phenotypes in mouse. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward (RPKM 4946.1) See more
Orthologs
human mouse all
See Mbp in Genome Data Viewer
Location:
18q12.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (79326738..79437310)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (78385304..78504226)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549036 Neighboring gene galanin receptor 1 Neighboring gene uncharacterized LOC108348833 Neighboring gene zinc finger protein 236 Neighboring gene similar to 60S ribosomal protein L9

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion. Choi BR, et al. Stroke, 2016 Feb. PMID 26670084
  2. The neuroprotective effect of picroside II via regulating the expression of myelin basic protein after cerebral ischemia injury in rats. Zhao L, et al. BMC Neurosci, 2014 Feb 14. PMID 24524292, Free PMC Article
  3. Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoforms. Ozgen H, et al. Biochim Biophys Acta, 2014 Mar. PMID 24321769
  4. Beneficial effect of TNF-α inhibition on diabetic peripheral neuropathy. Shi X, et al. J Neuroinflammation, 2013 Jun 4. PMID 23735240, Free PMC Article
  5. Altered hippocampal myelinated fiber integrity in a lithium-pilocarpine model of temporal lobe epilepsy: a histopathological and stereological investigation. Ye Y, et al. Brain Res, 2013 Jul 19. PMID 23727401

See all (80) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. The aberrant phase transition of MBP molecules from their cohesive to soluble and non-adhesive state is a mechanism triggering myelin breakdown in neuromyelitis optica.
    Title: Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases.
  2. hindlimb unweighting treatment induced damage of L5 DRG neurons, which was correlated with decreased total MBP protein expression, increased dgen-MBP expression, and reduced GDNF protein and mRNA expression
    Title: Effects of Hindlimb Unweighting on MBP and GDNF Expression and Morphology in Rat Dorsal Root Ganglia Neurons.
  3. Bilateral common carotid artery occlusion led to loss of myelin basic protein expression.
    Title: Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion.
  4. Study demonstrated that downregulation of tau severely impairs process outgrowth, oligodendrocyte differentiation, and sheet formation, and that MBP mRNA transport to the distal cellular extensions is disturbed
    Title: Downregulation of the microtubule associated protein tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.
  5. Protein levels of MBP were significantly greater in orbital frontal cortex (OFC) but not dorsal striatum (dSTR) of females as compared to males, suggesting that myelination is increased in OFC but similar in dSTR of females as compared to males
    Title: Sex differences in myelin-associated protein levels within and density of projections between the orbital frontal cortex and dorsal striatum of adult rats: implications for inhibitory control.
  6. MBP cell membrane localization is altered in the presence of galactolipids.
    Title: The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix.
  7. Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4.
    Title: Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.
  8. The expression of myelin basic protein was detected in accordance with the radially extending myelinated processes of the neurons in the cortex.
    Title: [Neuronal and glial antigen distribution in the columns of somatosensory cortex of rat brain (an immunohistochemical study)].
  9. Given the principle of the longest time window and the lowest therapeutic dose, the optimized therapeutic dose and time window should be injecting picroside II intraperitoneally with 10-20 mg/kg body weight at ischemia in cerebral ischemic injury.
    Title: The neuroprotective effect of picroside II via regulating the expression of myelin basic protein after cerebral ischemia injury in rats.
  10. The e-MBP isoform is exclusively present in OLN-93 cells.
    Title: Regulation of cell proliferation by nucleocytoplasmic dynamics of postnatal and embryonic exon-II-containing MBP isoforms.
Submit: New GeneRIF Correction See all GeneRIFs (26)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
protease binding ISO
Inferred from Sequence Orthology
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
  
structural constituent of myelin sheath IMP
Inferred from Mutant Phenotype
more info
 PubMed 
structural constituent of myelin sheath TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
aging IEP
Inferred from Expression Pattern
more info
 PubMed 
maintenance of permeability of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
  
maintenance of permeability of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
membrane organization ISO
Inferred from Sequence Orthology
more info
  
myelination IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
myelination ISO
Inferred from Sequence Orthology
more info
  
negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of heterotypic cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
positive regulation of chemokine (C-C motif) ligand 2 secretion IEA
Inferred from Electronic Annotation
more info
  
positive regulation of chemokine (C-C motif) ligand 2 secretion ISO
Inferred from Sequence Orthology
more info
  
positive regulation of interleukin-6 secretion IEA
Inferred from Electronic Annotation
more info
  
positive regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
  
positive regulation of metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
positive regulation of metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
response to fatty acid IEP
Inferred from Expression Pattern
more info
 PubMed 
response to mercury ion IEP
Inferred from Expression Pattern
more info
 PubMed 
response to progesterone IDA
Inferred from Direct Assay
more info
 PubMed 
response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
cell periphery IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
cell periphery ISO
Inferred from Sequence Orthology
more info
  
cell projection ISO
Inferred from Sequence Orthology
more info
  
compact myelin IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
compact myelin IDA
Inferred from Direct Assay
more info
 PubMed 
compact myelin ISO
Inferred from Sequence Orthology
more info
  
internode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
internode region of axon ISO
Inferred from Sequence Orthology
more info
  
intracellular IEA
Inferred from Electronic Annotation
more info
  
intracellular ISO
Inferred from Sequence Orthology
more info
  
myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
myelin sheath IEA
Inferred from Electronic Annotation
more info
  
myelin sheath ISO
Inferred from Sequence Orthology
more info
  
myelin sheath TAS
Traceable Author Statement
more info
 PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
plasma membrane IEA
Inferred from Electronic Annotation
more info
  
protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
myelin basic protein; Golli-Mbp
Names
MBP S
myelin basic protein Golli-mbp
myelin basic protein S

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025289.1 → NP_001020460.1  Golli-Mbp isoform 1

    See identical proteins and their annotated locations for NP_001020460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains 3 exons unique to Golli-Mbp and exon 1 of the classic Mbp. It encodes Golli-mbp isoform 1.
    Source sequence(s)
    BC084713
    UniProtKB/TrEMBL
    Q5XFW1
    Related
    ENSRNOP00000070157.1, ENSRNOT00000089879.1
    Conserved Domains (1) summary
    pfam01669
    Location:149 → 195
    Myelin_MBP; Myelin basic protein

  2. NM_001025291.1 → NP_001020462.1  myelin basic protein isoform 1

    See identical proteins and their annotated locations for NP_001020462.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest of the classic Mbp isoforms (1).
    Source sequence(s)
    AF439750, AI145512, AJ132898, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    UniProtKB/TrEMBL
    I7FKL4
    Related
    ENSRNOP00000022303.4, ENSRNOT00000022303.7
    Conserved Domains (1) summary
    pfam01669
    Location:16 → 194
    Myelin_MBP; Myelin basic protein

  3. NM_001025292.1 → NP_001020463.1  myelin basic protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks exon 2 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (2) that is missing a 26 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, AJ132897, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Related
    ENSRNOP00000055097.3, ENSRNOT00000058295.5
    Conserved Domains (1) summary
    pfam01669
    Location:16 → 168
    Myelin_MBP; Myelin basic protein

  4. NM_001025293.1 → NP_001020464.1  myelin basic protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks exon 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (3) that is missing a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, AJ132896, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Related
    ENSRNOP00000022280.5, ENSRNOT00000022280.5
    Conserved Domains (1) summary
    pfam01669
    Location:16 → 148
    Myelin_MBP; Myelin basic protein

  5. NM_001025294.1 → NP_001020465.1  myelin basic protein isoform 4

    See identical proteins and their annotated locations for NP_001020465.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks exons 2 and 5 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (4) that is missing a 26 aa and a 11 aa segment compared to isoform 1.
    Source sequence(s)
    AF439750, AI145512, CB586909, M25889
    UniProtKB/Swiss-Prot
    P02688
    Related
    ENSRNOP00000055098.3, ENSRNOT00000058296.5
    Conserved Domains (1) summary
    pfam01669
    Location:16 → 157
    Myelin_MBP; Myelin basic protein

  6. NM_017026.2 → NP_058722.1  myelin basic protein isoform 5

    See identical proteins and their annotated locations for NP_058722.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks exons 2 and 6 compared to transcript variant 1 and encodes one of the classic Mbp isoforms (5) that is missing a 26 aa and a 41 aa segment compared to isoform 1.
    Source sequence(s)
    AI145512, BC094522, CB586909
    UniProtKB/Swiss-Prot
    P02688
    Conserved Domains (1) summary
    pfam01669
    Location:16 → 122
    Myelin_MBP; Myelin basic protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    79326738..79437310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254997.3 → XP_006255059.1  myelin basic protein isoform X2

    See identical proteins and their annotated locations for XP_006255059.1

    Conserved Domains (1) summary
    pfam01669
    Location:149 → 327
    Myelin_MBP; Myelin basic protein

  2. XM_017600846.1 → XP_017456335.1  Golli-Mbp isoform X3

    Conserved Domains (1) summary
    pfam01669
    Location:149 → 281
    Myelin_MBP; Myelin basic protein

  3. XM_017600847.1 → XP_017456336.1  Golli-Mbp isoform X4

  4. XM_017600845.1 → XP_017456334.1  Golli-Mbp isoform X1

  5. XM_017600848.1 → XP_017456337.1  Golli-Mbp isoform X5

  6. XM_017600849.1 → XP_017456338.1  Golli-Mbp isoform X6

    Conserved Domains (1) summary
    pfam01669
    Location:149 → 249
    Myelin_MBP; Myelin basic protein

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    74493165..74602969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02688.3 GenPept UniProtKB/Swiss-Prot:P02688

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