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Kcnj1 potassium voltage-gated channel subfamily J member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24521, updated on 18-Apr-2019

Summary

Symbol
Kcnj1provided by RGD
Full Name
potassium voltage-gated channel subfamily J member 1provided by RGD
Primary source
RGD:2957
See related
Ensembl:ENSRNOG00000059005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kcnj; KAB-1; ROMK1; ROMK2; ROMK3; kir1.1; Kcnj1_v1; Kcnj1_v3
Summary
potassium channel involved in K+ secretion in the renal distal nephron [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 575.3) See more
Orthologs

Genomic context

See Kcnj1 in Genome Data Viewer
Location:
8q21
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (33490280..33519127)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (33453597..33454750)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene Neighboring gene potassium voltage-gated channel subfamily J member 5 Neighboring gene Fli-1 proto-oncogene, ETS transcription factor Neighboring gene uncharacterized LOC108351670 Neighboring gene ETS proto-oncogene 1, transcription factor Neighboring gene uncharacterized LOC102552230

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-activated inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-activated inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
inward rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cardiovascular system development ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to magnesium ion IDA
Inferred from Direct Assay
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G-protein activated inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
PubMed 
response to potassium ion IEP
Inferred from Expression Pattern
more info
PubMed 
tissue homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 1
Names
ATP-regulated potassium channel ROM-K
K+ channel protein
inward rectifier K(+) channel Kir1.1
potassium channel, inwardly rectifying subfamily J member 1
potassium voltage-gated channel subfamily J member 1, variant 1
potassium voltage-gated channel subfamily J member 1, variant 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309297.1NP_001296226.1  ATP-sensitive inward rectifier potassium channel 1 isoform 2

    See identical proteins and their annotated locations for NP_001296226.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as ROMK2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC127149
    Conserved Domains (1) summary
    pfam01007
    Location:24352
    IRK; Inward rectifier potassium channel
  2. NM_001309298.1NP_001296227.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296227.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as ROMK6.1) contains two alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC127149
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  3. NM_001309299.1NP_001296228.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296228.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4, also known as ROMK3.1) contains three alternate exons in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC127149
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  4. NM_001309301.1NP_001296230.1  ATP-sensitive inward rectifier potassium channel 1 isoform 3

    See identical proteins and their annotated locations for NP_001296230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5, also known as ROMK1.1) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1. Variants 3, 4 and 5 encode the same protein (isoform 3).
    Source sequence(s)
    AC127149
    Conserved Domains (1) summary
    cl21560
    Location:1198
    Ion_trans_2; Ion channel
  5. NM_017023.2NP_058719.2  ATP-sensitive inward rectifier potassium channel 1 isoform 1

    See identical proteins and their annotated locations for NP_058719.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as ROMK1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC127149
    UniProtKB/TrEMBL
    A0A0G2JYW2
    Related
    ENSRNOP00000070813.1, ENSRNOT00000081614.1
    Conserved Domains (1) summary
    pfam01007
    Location:43371
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    33490280..33519127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595458.1XP_017450947.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

    Conserved Domains (1) summary
    pfam01007
    Location:24352
    IRK; Inward rectifier potassium channel
  2. XM_008766044.2XP_008764266.1  ATP-sensitive inward rectifier potassium channel 1 isoform X1

    See identical proteins and their annotated locations for XP_008764266.1

    Conserved Domains (1) summary
    pfam01007
    Location:50378
    IRK; Inward rectifier potassium channel
  3. XM_008766047.2XP_008764269.1  ATP-sensitive inward rectifier potassium channel 1 isoform X2

    See identical proteins and their annotated locations for XP_008764269.1

    Conserved Domains (1) summary
    pfam01007
    Location:24352
    IRK; Inward rectifier potassium channel

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    32231456..32260138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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