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Jun Jun proto-oncogene, AP-1 transcription factor subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 24516, updated on 22-Nov-2020

Summary

Official Symbol
Junprovided by RGD
Official Full Name
Jun proto-oncogene, AP-1 transcription factor subunitprovided by RGD
Primary source
RGD:2943
See related
Ensembl:ENSRNOG00000026293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
transcription factor; acts as a protooncogene [RGD, Feb 2006]
Orthologs

Genomic context

See Jun in Genome Data Viewer
Location:
5q33
Exon count:
1
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (114011184..114014277, complement)
106 current Rn_Celera (GCF_000002265.2) 5 AC_000073.1 (108510040..108513133, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (117957730..117960823, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351004 Neighboring gene uncharacterized LOC108351136 Neighboring gene uncharacterized LOC100911221 Neighboring gene uncharacterized LOC102550339

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
HMG box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
cAMP response element binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding TAS
Traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
axon regeneration ISO
Inferred from Sequence Orthology
more info
 
cellular process ISO
Inferred from Sequence Orthology
more info
 
cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to potassium ion starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
eyelid development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
leading edge cell differentiation ISO
Inferred from Sequence Orthology
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA-templated transcription, initiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to muscle stretch ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to radiation IDA
Inferred from Direct Assay
more info
PubMed 
transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
euchromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor AP-1 complex ISO
Inferred from Sequence Orthology
more info
 
transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor AP-1
Names
AP1
Avian sarcoma virus 17 (v-jun) oncogene homolog
Jun oncogene
V-jun avian sarcoma virus 17 oncogene homolog
activator protein 1
proto-oncogene c-jun
v-jun sarcoma virus 17 oncogene homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021835.3NP_068607.1  transcription factor AP-1

    See identical proteins and their annotated locations for NP_068607.1

    Status: VALIDATED

    Source sequence(s)
    BC078738, BE113912, BF414978, CB740532, CK475341
    UniProtKB/Swiss-Prot
    P17325
    Related
    ENSRNOP00000011732.1, ENSRNOT00000011731.3
    Conserved Domains (2) summary
    cd14696
    Location:257317
    bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain
    pfam03957
    Location:5244
    Jun; Jun-like transcription factor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    114011184..114014277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    108510040..108513133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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