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Il6 interleukin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24498, updated on 29-Feb-2024

Summary

Official Symbol
Il6provided by RGD
Official Full Name
interleukin 6provided by RGD
Primary source
RGD:2901
See related
Ensembl:ENSRNOG00000010278 AllianceGenome:RGD:2901
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ILg6; Ifnb2
Summary
Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 22.5) and Thymus (RPKM 3.4) See more
Orthologs
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Genomic context

See Il6 in Genome Data Viewer
Location:
4q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (5889999..5894575, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (5214602..5219178, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (3043231..3047807)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 10, pseudogene 1 Neighboring gene dihydrofolate reductase, pseudogene 1 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member B6 Neighboring gene uncharacterized LOC120102202

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-6 receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables interleukin-6 receptor binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in T follicular helper cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in T follicular helper cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T-helper 17 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in T-helper 17 cell lineage commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
 
involved_in bone remodeling IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cytokine stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dexamethasone stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-17 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to prolactin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to protozoan ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within_positive_effect gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in germinal center B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in germinal center B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepatic immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in liver regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in liver regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lymphocyte costimulation IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of muscle organ development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of primary miRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of estradiol secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gliogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-21 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-21 production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transmission of nerve impulse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian sleep/wake cycle, non-REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to Gram-positive bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to activity ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to auditory stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to caffeine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to calcium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cytokine IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to yeast IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-6 receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-6 receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
interleukin-6
Names
IL-6
Interleukin 6 (interferon, beta 2)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012589.2NP_036721.1  interleukin-6 precursor

    See identical proteins and their annotated locations for NP_036721.1

    Status: PROVISIONAL

    Source sequence(s)
    M26744
    UniProtKB/Swiss-Prot
    P20607
    UniProtKB/TrEMBL
    A0A8I6A641, A6KJN3
    Related
    ENSRNOP00000013732.6, ENSRNOT00000013732.7
    Conserved Domains (1) summary
    cl02473
    Location:27210
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    5889999..5894575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)