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Snx14 sorting nexin 14 [ Mus musculus (house mouse) ]

Gene ID: 244962, updated on 30-Apr-2024

Summary

Official Symbol
Snx14provided by MGI
Official Full Name
sorting nexin 14provided by MGI
Primary source
MGI:MGI:2155664
See related
Ensembl:ENSMUSG00000032422 AllianceGenome:MGI:2155664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
YR-14; B830022K16; C330035N22Rik
Summary
Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in autophagosome maturation. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol and lysosome. Predicted to be active in late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.9), CNS E18 (RPKM 4.5) and 28 other tissues See more
Orthologs
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Genomic context

See Snx14 in Genome Data Viewer
Location:
9 E3.1; 9 47.24 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88258805..88320982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88376755..88438929, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24855 Neighboring gene microRNA 12205 Neighboring gene 5' nucleotidase, ecto Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10573 Neighboring gene STARR-seq mESC enhancer starr_24856 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9772 Neighboring gene small nucleolar RNA, C/D box 50A Neighboring gene small nucleolar RNA host gene 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359958.2NP_001346887.2  sorting nexin-14 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116713, CT025673
    UniProtKB/Swiss-Prot
    B0V2Q4, G3UWA3, Q8BHY8
    UniProtKB/TrEMBL
    G3UX33
    Related
    ENSMUSP00000133533.3, ENSMUST00000174806.9
    Conserved Domains (4) summary
    cd06877
    Location:564686
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130299
    PXA; PXA domain
    pfam08628
    Location:807911
    Nexin_C; Sorting nexin C terminal
  2. NM_172926.4NP_766514.3  sorting nexin-14 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116713, CT025673
    Consensus CDS
    CCDS23387.2
    UniProtKB/Swiss-Prot
    B0V2Q4, G3UWA3, Q8BHY8
    UniProtKB/TrEMBL
    A0A6Q6RCM4
    Related
    ENSMUSP00000130116.3, ENSMUST00000165315.9
    Conserved Domains (4) summary
    cd06877
    Location:555677
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    cd08722
    Location:340466
    RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
    pfam02194
    Location:130299
    PXA; PXA domain
    pfam08628
    Location:798902
    Nexin_C; Sorting nexin C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    88258805..88320982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155012.1XP_036010905.1  sorting nexin-14 isoform X1

    UniProtKB/TrEMBL
    Q80XP2
    Conserved Domains (3) summary
    cd06877
    Location:179301
    PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
    pfam08628
    Location:422526
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:181
    RGS; Regulator of G protein signaling (RGS) domain superfamily