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Prss35 protease, serine 35 [ Mus musculus (house mouse) ]

Gene ID: 244954, updated on 26-Sep-2022

Summary

Official Symbol
Prss35provided by MGI
Official Full Name
protease, serine 35provided by MGI
Primary source
MGI:MGI:2444800
See related
Ensembl:ENSMUSG00000033491 AllianceGenome:MGI:2444800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P3D9; 6030424L22Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in embryo; head; interstitium of the testis; and primary palate. Orthologous to human PRSS35 (serine protease 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 17.6), limb E14.5 (RPKM 14.0) and 6 other tissues See more
Orthologs
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Genomic context

See Prss35 in Genome Data Viewer
Location:
9; 9 E3.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86625291..86640496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86743240..86758443)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene predicted gene, 22138 Neighboring gene synaptosomal-associated protein 91 Neighboring gene predicted gene, 39389

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
inactive serine protease 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178738.3NP_848853.2  inactive serine protease 35 precursor

    See identical proteins and their annotated locations for NP_848853.2

    Status: VALIDATED

    Source sequence(s)
    BB659182, BC075675
    Consensus CDS
    CCDS40714.1
    UniProtKB/Swiss-Prot
    Q8C0F9, Q8C0L5
    Related
    ENSMUSP00000035271.7, ENSMUST00000036426.13
    Conserved Domains (1) summary
    cl21584
    Location:124389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86625291..86640496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155009.1XP_036010902.1  inactive serine protease 35 isoform X1

    UniProtKB/Swiss-Prot
    Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006511170.5XP_006511233.1  inactive serine protease 35 isoform X1

    See identical proteins and their annotated locations for XP_006511233.1

    UniProtKB/Swiss-Prot
    Q8C0F9, Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006511171.5XP_006511234.1  inactive serine protease 35 isoform X1

    See identical proteins and their annotated locations for XP_006511234.1

    UniProtKB/Swiss-Prot
    Q8C0F9, Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...