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Il1a interleukin 1 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 24493, updated on 28-Oct-2021

Summary

Official Symbol
Il1aprovided by RGD
Official Full Name
interleukin 1 alphaprovided by RGD
Primary source
RGD:2890
See related
EnsemblRapid:ENSRNOG00000004575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IL-1F1; IL-1 alpha
Summary
proinflammatory cytokine [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 64.8), Lung (RPKM 41.1) and 6 other tissues See more
Orthologs
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Genomic context

See Il1a in Genome Data Viewer
Location:
3q36
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (116526601..116537055, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (121824712..121836122, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549385 Neighboring gene cytoskeleton associated protein 2-like Neighboring gene uncharacterized LOC120101660 Neighboring gene interleukin 1 beta

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-1 receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acute inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in connective tissue replacement involved in inflammatory response wound healing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ectopic germ cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in fever generation IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in keratinization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of establishment of Sertoli cell barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immature T cell proliferation in thymus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of prostaglandin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of nitric-oxide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of sensory perception of pain IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to copper ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to copper ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to copper ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ozone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017019.2NP_058715.1  interleukin-1 alpha

    See identical proteins and their annotated locations for NP_058715.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000118
    UniProtKB/Swiss-Prot
    P16598
    Related
    ENSRNOP00000006113.7, ENSRNOT00000006113.9
    Conserved Domains (2) summary
    smart00125
    Location:131270
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1109
    IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    116526601..116537055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104245.1XP_038960173.1  interleukin-1 alpha isoform X2

    Related
    ENSRNOP00000006126.7, ENSRNOT00000006126.8
    Conserved Domains (2) summary
    pfam02394
    Location:1107
    IL1_propep; Interleukin-1 propeptide
    cl00094
    Location:106212
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
  2. XM_039104244.1XP_038960172.1  interleukin-1 alpha isoform X1

    Conserved Domains (2) summary
    smart00125
    Location:131270
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1109
    IL1_propep; Interleukin-1 propeptide
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