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Igf2 insulin-like growth factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24483, updated on 25-Jun-2018
Official Symbol
Igf2provided by RGD
Official Full Name
insulin-like growth factor 2provided by RGD
Primary source
RGD:2870
See related
Ensembl:ENSRNOG00000020369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IGFII; RNIGF2
Summary
a mitogenic growth factor; may have a role in fetal development [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 612.5), Liver (RPKM 176.8) and 2 other tissues See more
Orthologs
See Igf2 in Genome Data Viewer
Location:
1q41
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215828102..215839081, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (222722921..222733868, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547221 Neighboring gene uncharacterized LOC102548505 Neighboring gene uncharacterized LOC100909737 Neighboring gene microRNA 483 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene insulin 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic placenta development ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic placenta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
exocrine pancreas development IEA
Inferred from Electronic Annotation
more info
 
exocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway via phosphatidylinositol 3-kinase IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway via phosphatidylinositol 3-kinase ISO
Inferred from Sequence Orthology
more info
 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of glycogen (starch) synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen (starch) synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of steroid hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of histone modification IEA
Inferred from Electronic Annotation
more info
 
regulation of histone modification ISO
Inferred from Sequence Orthology
more info
 
regulation of histone modification ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to nicotine IDA
Inferred from Direct Assay
more info
PubMed 
response to nicotine IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
striated muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
striated muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
insulin-like growth factor II
Names
IGF-II
Insulin-like growth factor II (somatomedin A)
MSA
insulin-like growth factor II (IGF-II)
insulin-like growth factor II isoform 2 variant 4 preprotein
multiplication-stimulating activity
multiplication-stimulating polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190162.1NP_001177091.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001177091.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC098563, X13101
    UniProtKB/Swiss-Prot
    P01346
    UniProtKB/TrEMBL
    M9NW49
    Related
    ENSRNOP00000066983.1, ENSRNOT00000073850.3
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  2. NM_001190163.1NP_001177092.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001177092.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC098563, X14833
    UniProtKB/Swiss-Prot
    P01346
    UniProtKB/TrEMBL
    M9NW49
    Related
    ENSRNOP00000047037.3, ENSRNOT00000050760.3
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  3. NM_031511.2NP_113699.2  insulin-like growth factor II isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_113699.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098563, X14834
    UniProtKB/Swiss-Prot
    P01346
    UniProtKB/TrEMBL
    A0A0G2JTA6
    Related
    ENSRNOP00000068633.1, ENSRNOT00000080246.1
    Conserved Domains (2) summary
    cd04368
    Location:39102
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:123177
    IGF2_C; Insulin-like growth factor II E-peptide

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    215828102..215839081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230665.2XP_006230727.1  insulin-like growth factor II isoform X3

    See identical proteins and their annotated locations for XP_006230727.1

    UniProtKB/Swiss-Prot
    P01346
    UniProtKB/TrEMBL
    M9NW49
    Related
    ENSRNOP00000070557.1, ENSRNOT00000089171.1
    Conserved Domains (2) summary
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
  2. XM_008760074.2XP_008758296.1  insulin-like growth factor II isoform X2

    Conserved Domains (1) summary
    cd04368
    Location:192255
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. XM_006230664.3XP_006230726.1  insulin-like growth factor II isoform X1

    See identical proteins and their annotated locations for XP_006230726.1

    Conserved Domains (2) summary
    cd04368
    Location:192255
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
    pfam08365
    Location:276330
    IGF2_C; Insulin-like growth factor II E-peptide

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    195432460..195442561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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