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Ifnb1 interferon beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24481, updated on 13-Apr-2024

Summary

Official Symbol
Ifnb1provided by RGD
Official Full Name
interferon beta 1provided by RGD
Primary source
RGD:2865
See related
Ensembl:ENSRNOG00000006268 AllianceGenome:RGD:2865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ifnb; If1da1
Summary
Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Ifnb1 in Genome Data Viewer
Location:
5q32
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (108066650..108067487, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103020758..103021595, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (106865192..106865746, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene focadhesin Neighboring gene 3-hydroxyacyl-CoA dehydratase 4 Neighboring gene interferon, alpha 4 Neighboring gene interferon, alpha 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloramphenicol O-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables type I interferon receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dsDNA IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dsRNA IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to dsRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to exogenous dsRNA IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endoplasmic reticulum unfolded protein response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within humoral immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Lewy body formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Lewy body formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood-brain barrier permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell adhesion molecule production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of matrix metallopeptidase secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mononuclear cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuroinflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interferon beta
Names
IFN-beta
interferon 1da1
interferon beta 1, fibroblast

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019127.2NP_062000.1  interferon beta precursor

    See identical proteins and their annotated locations for NP_062000.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P70499
    UniProtKB/TrEMBL
    A0A7R8GV74
    Related
    ENSRNOP00000008225.1, ENSRNOT00000008224.3
    Conserved Domains (1) summary
    pfam00143
    Location:27182
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    108066650..108067487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)