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Iapp islet amyloid polypeptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 24476, updated on 4-Sep-2021

Summary

Official Symbol
Iappprovided by RGD
Official Full Name
islet amyloid polypeptideprovided by RGD
Primary source
RGD:2854
See related
Ensembl:ENSRNOG00000012417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
pancreatic islet hormone found in the pancreatic amyloid deposits [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 24.5), Testes (RPKM 7.6) and 5 other tissues See more
Orthologs
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Genomic context

See Iapp in Genome Data Viewer
Location:
4q44
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175237013..175244373)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176509863..176517903)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family member 1A3 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene solute carrier organic anion transporter family, member 1A5 Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
islet amyloid polypeptide
Names
DAP
amylin
diabetes-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012586.2NP_036718.1  islet amyloid polypeptide precursor

    See identical proteins and their annotated locations for NP_036718.1

    Status: PROVISIONAL

    Source sequence(s)
    X52820
    UniProtKB/Swiss-Prot
    P12969
    Conserved Domains (1) summary
    pfam00214
    Location:3677
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    175237013..175244373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237614.4XP_006237676.1  islet amyloid polypeptide isoform X1

    See identical proteins and their annotated locations for XP_006237676.1

    UniProtKB/Swiss-Prot
    P12969
    Related
    ENSRNOP00000016614.1
    Conserved Domains (1) summary
    pfam00214
    Location:3677
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
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