Iapp islet amyloid polypeptide [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Iappprovided by RGD
Official Full Name: islet amyloid polypeptideprovided by RGD
Primary source: RGD:2854
See related: Ensembl:ENSRNOG00000082704 AllianceGenome:RGD:2854
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables hormone activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; and eating behavior. Predicted to be located in inclusion body. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human IAPP (islet amyloid polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Lung (RPKM 24.5), Testes (RPKM 7.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q44

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176968097..176975363)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (175237107..175244373)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176509863..176517903)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.
Title: Interspecies Variation Affects Islet Amyloid Polypeptide Membrane Binding.
Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes.
Title: Site-Specific Alkylation of the Islet Amyloid Polypeptide Accelerates Self-Assembly and Potentiates Perturbation of Lipid Membranes.
Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.
Title: Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats.
Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.
Title: Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells.
The study presents the characterization of the structure ensemble of human IAPP, as well as the differences between human IAPP and its non-amyloidogenic homologous such as rat IAPP and illuminates the amyloidosis mechanism of IAPP.
Title: All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints.
These results are the first to demonstrate the role of rIAPP amyloid oligomers in the development of streptozotocin-induced diabetes in rats. The IAPP amyloid oligomers are biomarkers of the onset and progression of diabetes.
Title: Novel insight into streptozotocin-induced diabetic rats from the protein misfolding perspective.
IAPP role in the pancreatic islet cell damage in the Type 2 diabetes mellitus.
Title: Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo.
this study reinforces the notion that IAPP amyloidogenesis is governed by precise intermolecular interactions involving specific Asn side chains.
Title: Role of Site-Specific Asparagine Deamidation in Islet Amyloid Polypeptide Amyloidogenesis: Key Contributions of Residues 14 and 21.
C4BP protects beta-cells from IAPP cytotoxicity by modulating IAPP fibril formation extracellularly and also, after uptake by the cells, by enhancing cholesterol synthesis.
Title: C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity.
ventromedial hypothalamus amylin signaling is required for full leptin signaling and protection from high fat diet induced obesity
Title: Endogenous VMH amylin signaling is required for full leptin signaling and protection from diet-induced obesity.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142197 (e-PCR)
- UniSTS:231447

D4Mgh29 (e-PCR), detects polymorphism
- UniSTS:227702

Iapp (e-PCR), detects polymorphism
- UniSTS:256681

D4Arb1 (e-PCR)
- UniSTS:240306

D4Wox12 (e-PCR)
- UniSTS:119236

D4Got138 (e-PCR)
- UniSTS:113897

RH94796 (e-PCR)
- UniSTS:120043

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amylin receptor 1 signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amylin receptor 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor 1 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amylin receptor 2 signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amylin receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amylin receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within amylin receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within amylin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amylin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of bone resorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP/PKA signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cAMP/PKA signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in inclusion body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in secretory granule	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: islet amyloid polypeptide

Names: DAP; amylin; diabetes-associated peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.