Format

Send to:

Choose Destination

Hspa1a heat shock protein family A (Hsp70) member 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24472, updated on 9-Aug-2021

Summary

Official Symbol
Hspa1aprovided by RGD
Official Full Name
heat shock protein family A (Hsp70) member 1Aprovided by RGD
Primary source
RGD:1593284
See related
Ensembl:ENSRNOG00000050647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HSP72; Hspa1; Hspa1b; HSP70.1; Hsp70-1
Summary
heat inducible gene; induced by global ischemia and kainic acid-induced seizures [RGD, Feb 2006]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hspa1a in Genome Data Viewer
Location:
20p12
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3855104..3859148)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4877638..4880112, complement)

Chromosome 20 - NC_051355.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene heat shock protein family A (Hsp70) member 1 like Neighboring gene heat shock protein family A (Hsp70) member 1B Neighboring gene uncharacterized LOC102549726 Neighboring gene small nucleolar RNA SNORD48

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Hspa1a gene: The Hspa1a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, zebrafish, fruit fly, S.cerevisiae, K.lactis, E.gossypii, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables denatured protein binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disaggregase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular heat acclimation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lysosomal transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription from RNA polymerase II promoter in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to unfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to unfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock 70 kDa protein 1B
Names
HSP70-1/HSP70-2
HSP70.1/2
HSP70.1/HSP70.2
Heat shock 70 kDa protein 1
Heat shock 70 kDa protein 1A
heat shock 70 kDa protein 1/2
heat shock 70 kDa protein 1A/1B
heat shock 70kD protein 1A
heat shock protein 70-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031971.2NP_114177.2  heat shock 70 kDa protein 1B

    See identical proteins and their annotated locations for NP_114177.2

    Status: PROVISIONAL

    Source sequence(s)
    BX883045
    UniProtKB/Swiss-Prot
    P0DMW0, P0DMW1
    Related
    ENSRNOP00000075599.1, ENSRNOT00000081924.1
    Conserved Domains (2) summary
    cd10233
    Location:6381
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1641
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051355.1 Reference mRatBN7.2 Primary Assembly

    Range
    3855104..3859148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center