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Hspa8 heat shock protein family A (Hsp70) member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24468, updated on 5-Sep-2021

Summary

Official Symbol
Hspa8provided by RGD
Official Full Name
heat shock protein family A (Hsp70) member 8provided by RGD
Primary source
RGD:621725
See related
Ensembl:ENSRNOG00000034066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hsc70
Summary
member of the hsp70 protein; expressed in unstressed cells [RGD, Feb 2006]
Annotation information
Note: The functional gene for Hspa8 is located on Rno8. It was incorrectly placed on Rno5 on the reference assembly for NCBI Build 4.1 at the location of one of its pseudogenes. The correct GeneID for the pseudogene is geneID:100190885. [17 Jun 2014]
Expression
Biased expression in Brain (RPKM 7049.0), Kidney (RPKM 6652.5) and 9 other tissues See more
Orthologs
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Genomic context

See Hspa8 in Genome Data Viewer
Location:
8q22
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (41183397..41187260)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (44989401..44993261)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351686 Neighboring gene CXADR-like membrane protein Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene similar to Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) Neighboring gene hypothetical protein LOC688977

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC114311

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables A1 adenosine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ADP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin-uncoating ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables clathrin-uncoating ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disaggregase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in G1/S transition of mitotic cell cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in axo-dendritic transport IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cellular protein complex disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in chaperone-mediated autophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within chaperone-mediated autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in chaperone-mediated autophagy translocation complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone-mediated autophagy translocation complex disassembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in clathrin coat disassembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within clathrin coat disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in kidney development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in late endosomal microautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in late endosomal microautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in maintenance of postsynaptic specialization structure EXP
Inferred from Experiment
more info
PubMed 
involved_in maintenance of postsynaptic specialization structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of postsynaptic specialization structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation by host of viral process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hydrogen peroxide-induced cell death IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of supramolecular fiber organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation by host of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lysosomal membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein folding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transmembrane import into intracellular organelle IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein complex stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nickel cation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to odorant IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in sensory perception of smell IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in skeletal muscle tissue development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in slow axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in slow axonal transport IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in synaptic vesicle uncoating IC
Inferred by Curator
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of Prp19 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Prp19 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
part_of chaperone complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glycinergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glycinergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glycinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glycinergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal lumen TAS
Traceable Author Statement
more info
 
located_in lysosomal matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
part_of messenger ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor ribbon synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in terminal bouton HDA PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock cognate 71 kDa protein
Names
Heat shock cognate protein 70
heat shock 70kD protein 8
heat shock 70kDa protein 8
heat shock protein 8
heat shock protein A8
NP_077327.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024351.2NP_077327.1  heat shock cognate 71 kDa protein

    See identical proteins and their annotated locations for NP_077327.1

    Status: VALIDATED

    Source sequence(s)
    BC061547, BC098914
    UniProtKB/Swiss-Prot
    P63018
    Related
    ENSRNOP00000042159.5, ENSRNOT00000044608.5
    Conserved Domains (1) summary
    PTZ00009
    Location:1613
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    41183397..41187260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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