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Hydin HYDIN, axonemal central pair apparatus protein [ Mus musculus (house mouse) ]

Gene ID: 244653, updated on 12-May-2024

Summary

Official Symbol
Hydinprovided by MGI
Official Full Name
HYDIN, axonemal central pair apparatus proteinprovided by MGI
Primary source
MGI:MGI:2389007
See related
Ensembl:ENSMUSG00000059854 AllianceGenome:MGI:2389007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hy3; hy-3; hyrh; 672398; Gm9558; 4932703P14; A830061H17; 1700034M11Rik; 4930545D19Rik; AC069308.21gm4
Summary
Acts upstream of or within several processes, including axonemal central apparatus assembly; trachea development; and ventricular system development. Located in axonemal central pair projection. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 5. Orthologous to human HYDIN (HYDIN axonemal central pair apparatus protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 10.5), lung adult (RPKM 1.1) and 1 other tissue See more
Orthologs
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Genomic context

See Hydin in Genome Data Viewer
Location:
8 D3- E1; 8 57.5 cM
Exon count:
89
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110993600..111336885)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110266968..110610253)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112741810-112741919 Neighboring gene STARR-seq mESC enhancer starr_22674 Neighboring gene cap methyltransferase 2 Neighboring gene predicted gene, 39249 Neighboring gene predicted gene, 26832 Neighboring gene STARR-seq mESC enhancer starr_22675 Neighboring gene predicted gene, 23627 Neighboring gene predicted gene, 35676 Neighboring gene STARR-seq mESC enhancer starr_22677 Neighboring gene predicted gene, 21283 Neighboring gene STARR-seq mESC enhancer starr_22680 Neighboring gene STARR-positive B cell enhancer ABC_E5040 Neighboring gene nuclear encoded tRNA glycine 11 (anticodon GCC) Neighboring gene nuclear encoded tRNA glycine 10 (anticodon GCC) Neighboring gene Vac14 homolog (S. cerevisiae)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axonemal central apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonemal central pair projection IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
hydrocephalus-inducing protein
Names
hydrocephalus 3
protein Hy-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172916.2NP_766504.3  hydrocephalus-inducing protein

    See identical proteins and their annotated locations for NP_766504.3

    Status: VALIDATED

    Source sequence(s)
    AY173049
    Consensus CDS
    CCDS40476.1
    UniProtKB/Swiss-Prot
    Q3UQ06, Q68ED1, Q80W93, Q8BRL9, Q8CDF4
    Related
    ENSMUSP00000046204.7, ENSMUST00000043141.7
    Conserved Domains (4) summary
    TIGR02794
    Location:23122464
    tolA_full; TolA protein
    pfam00635
    Location:249314
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam13863
    Location:22962403
    DUF4200; Domain of unknown function (DUF4200)
    pfam15780
    Location:559659
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110993600..111336885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243552.1XP_030099412.1  hydrocephalus-inducing protein isoform X1

    Conserved Domains (5) summary
    PRK00279
    Location:22282284
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20532254
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22922482
    DUF5401; Family of unknown function (DUF5401)
  2. XM_030243556.1XP_030099416.1  hydrocephalus-inducing protein isoform X5

    Conserved Domains (5) summary
    PRK00279
    Location:22262282
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20532252
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22902480
    DUF5401; Family of unknown function (DUF5401)
  3. XM_030243554.1XP_030099414.1  hydrocephalus-inducing protein isoform X3

    Conserved Domains (5) summary
    PRK00279
    Location:22272283
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20532253
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22912481
    DUF5401; Family of unknown function (DUF5401)
  4. XM_030243553.1XP_030099413.1  hydrocephalus-inducing protein isoform X2

    Conserved Domains (5) summary
    PRK00279
    Location:22272283
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20522253
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22912481
    DUF5401; Family of unknown function (DUF5401)
  5. XM_030243555.1XP_030099415.1  hydrocephalus-inducing protein isoform X4

    Conserved Domains (5) summary
    PRK00279
    Location:22262282
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20522252
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22902480
    DUF5401; Family of unknown function (DUF5401)
  6. XM_030243557.1XP_030099417.1  hydrocephalus-inducing protein isoform X6

    Conserved Domains (5) summary
    PRK00279
    Location:22242280
    adk; adenylate kinase; Reviewed
    cl27657
    Location:226291
    Motile_Sperm; MSP (Major sperm protein) domain
    pfam15780
    Location:538637
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
    pfam17213
    Location:20522250
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:22882478
    DUF5401; Family of unknown function (DUF5401)
  7. XM_030243560.2XP_030099420.1  hydrocephalus-inducing protein isoform X8

    Conserved Domains (3) summary
    PRK00279
    Location:604660
    adk; adenylate kinase; Reviewed
    pfam17213
    Location:429630
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:668858
    DUF5401; Family of unknown function (DUF5401)
  8. XM_030243558.2XP_030099418.1  hydrocephalus-inducing protein isoform X7

    Conserved Domains (3) summary
    PRK00279
    Location:657713
    adk; adenylate kinase; Reviewed
    pfam17213
    Location:482683
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:721911
    DUF5401; Family of unknown function (DUF5401)
  9. XM_030243559.2XP_030099419.1  hydrocephalus-inducing protein isoform X8

    Conserved Domains (3) summary
    PRK00279
    Location:604660
    adk; adenylate kinase; Reviewed
    pfam17213
    Location:429630
    Hydin_ADK; Hydin Adenylate kinase-like domain
    pfam17380
    Location:668858
    DUF5401; Family of unknown function (DUF5401)
  10. XM_030243561.2XP_030099421.1  hydrocephalus-inducing protein isoform X9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172915.1: Suppressed sequence

    Description
    NM_172915.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.