Hprt1 hypoxanthine phosphoribosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hprt1provided by RGD
Full Name: hypoxanthine phosphoribosyltransferase 1provided by RGD
Primary source: RGD:2826
See related: Ensembl:ENSRNOG00000031367 AllianceGenome:RGD:2826
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hprt; Hgprtase
Summary: Enables hypoxanthine phosphoribosyltransferase activity. Involved in cellular response to insulin stimulus; hypoxanthine metabolic process; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in HRPT-related hyperuricemia and Lesch-Nyhan syndrome. Orthologous to human HPRT1 (hypoxanthine phosphoribosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Heart (RPKM 786.1), Adrenal (RPKM 493.2) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: Xq36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (137655744..137687718)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (132736175..132768149)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (158196640..158228815, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The combination of hprt and gapdh is the best compound reference genes in the fetal rat hippocampus.
Title: The combination of hprt and gapdh is the best compound reference genes in the fetal rat hippocampus.
Thsi study validated the Hprt1, Actb, Mapk6 or B2m and showed that any one or combination of two of them are good reference genes for normalization of mRNA expression in qPCR experiments in the spinal cord and RVM in the CFA model of inflammatory injury.
Title: Validation of four reference genes for quantitative mRNA expression studies in a rat model of inflammatory injury.
Report frequency of phenacetin induced gtp point mutations in the liver and kidney of gpt transgenic rats.
Title: Genotoxicity of phenacetin in the kidney and liver of Sprague-Dawley gpt delta transgenic rats in 26-week and 52-week repeated-dose studies.
Mutations in the HPRT gene were evaluated in female Big Blue rats and found not to be induced by leucomalachite green administered in a chronic feeding study.
Title: Analysis of mutations and bone marrow micronuclei in Big Blue rats fed leucomalachite green.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hprt (e-PCR), detects polymorphism
- UniSTS:265222

PMC107853P1 (e-PCR)
- UniSTS:270126

RH134366 (e-PCR)
- UniSTS:217648

PMC23548P1 (e-PCR)
- UniSTS:272205

PMC124351P1 (e-PCR)
- UniSTS:270464

Hprt (e-PCR), detects polymorphism
- UniSTS:528044

GDB:192504 (e-PCR)
- UniSTS:98989

PMC321611P2 (e-PCR)
- UniSTS:273124

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables guanine phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables guanine phosphoribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hypoxanthine phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxanthine phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hypoxanthine phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hypoxanthine phosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AMP salvage	ISO Inferred from Sequence Orthology more info
involved_in GMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in GMP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in GMP salvage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within GMP salvage	ISO Inferred from Sequence Orthology more info
involved_in GMP salvage	ISO Inferred from Sequence Orthology more info
involved_in IMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in IMP salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP salvage	IEA Inferred from Electronic Annotation more info
involved_in IMP salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within central nervous system neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in guanine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in guanine salvage	ISO Inferred from Sequence Orthology more info
involved_in guanine salvage	ISS Inferred from Sequence or Structural Similarity more info
involved_in hypoxanthine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hypoxanthine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hypoxanthine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine salvage	ISO Inferred from Sequence Orthology more info
involved_in hypoxanthine salvage	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in purine nucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within purine ribonucleoside salvage	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside salvage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within striatum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hypoxanthine-guanine phosphoribosyltransferase

Names: HGPRT; hypoxanthine guanine phosphoribosyl transferase 1; hypoxanthine phosphoribosyl transferase

NP_036715.1

EC 2.4.2.8

XP_038955375.1

EC 2.4.2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012583.2 → NP_036715.1 hypoxanthine-guanine phosphoribosyltransferase

See identical proteins and their annotated locations for NP_036715.1

Status: PROVISIONAL

Source sequence(s)

BC098629

UniProtKB/Swiss-Prot

P27605, P70469, Q4KMC5, Q62926

UniProtKB/TrEMBL

A6KUK3, A6KUK4

Related

ENSRNOP00000043388.5, ENSRNOT00000045153.5

Conserved Domains (1) summary

cl00309
Location:6 → 218

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

137655744..137687718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099447.2 → XP_038955375.1 hypoxanthine-guanine phosphoribosyltransferase isoform X1

UniProtKB/TrEMBL

A6KUK3

Related

ENSRNOP00000082017.2, ENSRNOT00000109953.2

Conserved Domains (1) summary

cl00309
Location:13 → 218

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain