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Abcc12 ATP-binding cassette, sub-family C member 12 [ Mus musculus (house mouse) ]

Gene ID: 244562, updated on 2-Nov-2024

Summary

Official Symbol
Abcc12provided by MGI
Official Full Name
ATP-binding cassette, sub-family C member 12provided by MGI
Primary source
MGI:MGI:2441679
See related
Ensembl:ENSMUSG00000036872 AllianceGenome:MGI:2441679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRP9; 4930467B22Rik
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in mitochondrion. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human ABCC12 (ATP binding cassette subfamily C member 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 25.1) See more
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Genomic context

See Abcc12 in Genome Data Viewer
Location:
8 C3; 8 42.06 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (87231197..87307317, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (86504568..86580688, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33687 Neighboring gene predicted gene, 24490 Neighboring gene STARR-seq mESC enhancer starr_22180 Neighboring gene STARR-seq mESC enhancer starr_22182 Neighboring gene STARR-positive B cell enhancer ABC_E10515 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene predicted gene, 22305 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:89230711-89230912 Neighboring gene siah E3 ubiquitin protein ligase 1A Neighboring gene predicted gene 10638

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 12
Names
ATP-binding cassette transporter sub-family C member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
multidrug resistance-associated protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172912.4NP_766500.3  ATP-binding cassette sub-family C member 12

    See identical proteins and their annotated locations for NP_766500.3

    Status: VALIDATED

    Source sequence(s)
    AC132147, AC159262
    Consensus CDS
    CCDS22502.1
    UniProtKB/Swiss-Prot
    B2RRF4, Q80WJ2, Q80WJ3, Q80WJ6, Q8C0P3
    Related
    ENSMUSP00000079014.4, ENSMUST00000080115.10
    Conserved Domains (1) summary
    TIGR00957
    Location:431366
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    87231197..87307317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530984.4XP_006531047.1  ATP-binding cassette sub-family C member 12 isoform X1

    See identical proteins and their annotated locations for XP_006531047.1

    UniProtKB/Swiss-Prot
    B2RRF4, Q80WJ2, Q80WJ3, Q80WJ6, Q8C0P3
    Related
    ENSMUSP00000122402.2, ENSMUST00000131423.8
    Conserved Domains (1) summary
    TIGR00957
    Location:431366
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  2. XM_036154037.1XP_036009930.1  ATP-binding cassette sub-family C member 12 isoform X4

    Conserved Domains (1) summary
    PLN03130
    Location:6827
    PLN03130; ABC transporter C family member; Provisional
  3. XM_006530985.5XP_006531048.1  ATP-binding cassette sub-family C member 12 isoform X2

    Conserved Domains (1) summary
    TIGR00957
    Location:1983
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  4. XM_006530986.3XP_006531049.1  ATP-binding cassette sub-family C member 12 isoform X3

    Conserved Domains (1) summary
    TIGR00957
    Location:53931
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)

RNA

  1. XR_003947278.1 RNA Sequence

  2. XR_003947279.1 RNA Sequence

    Related
    ENSMUST00000156610.8