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Hmox1 heme oxygenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24451, updated on 27-Nov-2024

Summary

Official Symbol
Hmox1provided by RGD
Official Full Name
heme oxygenase 1provided by RGD
Primary source
RGD:2806
See related
EnsemblRapid:ENSRNOG00000014117 AllianceGenome:RGD:2806
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32
Summary
Enables several functions, including heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and phospholipase D activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and regulation of gene expression. Located in caveola; endoplasmic reticulum; and nucleus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1679.3), Adrenal (RPKM 142.6) and 3 other tissues See more
Orthologs
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Genomic context

See Hmox1 in Genome Data Viewer
Location:
19p11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (13452365..13479823)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (13466287..13474082)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (14508634..14515455)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene HMG-box containing 4 Neighboring gene uncharacterized LOC102556139 Neighboring gene target of myb1 membrane trafficking protein Neighboring gene uncharacterized LOC134483111 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene RASD family, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arachidonate omega-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables heme oxygenase (decyclizing) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heme oxygenase (decyclizing) activity IEA
Inferred from Electronic Annotation
more info
 
enables heme oxygenase (decyclizing) activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
enables structural molecule activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cisplatin IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to cisplatin ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in heme catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heme catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heme catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heme metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in heme oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heme oxidation IEA
Inferred from Electronic Annotation
more info
 
involved_in heme oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in liver regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organismal-level iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ferroptosis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ferroptosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mast cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mast cell degranulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to 3-methylcholanthrene IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to arachidonate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estrogen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in small GTPase-mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in wound healing involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in wound healing involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heme oxygenase 1
Names
heme oxygenase (decycling) 1
heme oxygenase (decyclizing) 1
NP_036712.1
XP_038953398.1
XP_063133845.1
XP_063133846.1
XP_063133847.1
XP_063133848.1
XP_063133849.1
XP_063133850.1
XP_063133851.1
XP_063133852.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012580.2NP_036712.1  heme oxygenase 1

    See identical proteins and their annotated locations for NP_036712.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091164
    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A0A8L2UJE9, A6JY98
    Related
    ENSRNOP00000019192.6, ENSRNOT00000019192.8
    Conserved Domains (2) summary
    cd19165
    Location:127154
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:11216
    Heme_oxygenase; Heme oxygenase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    13452365..13479823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277782.1XP_063133852.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  2. XM_063277781.1XP_063133851.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  3. XM_063277779.1XP_063133849.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  4. XM_063277778.1XP_063133848.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  5. XM_063277780.1XP_063133850.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  6. XM_063277777.1XP_063133847.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  7. XM_063277775.1XP_063133845.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98
  8. XM_039097470.2XP_038953398.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A0A8L2UJE9, A6JY98
    Conserved Domains (2) summary
    cd19165
    Location:127154
    HemeO; kinked helix [structural motif]
    pfam01126
    Location:11216
    Heme_oxygenase; Heme oxygenase
  9. XM_063277776.1XP_063133846.1  heme oxygenase 1 isoform X1

    UniProtKB/Swiss-Prot
    P06762, Q5BK87
    UniProtKB/TrEMBL
    A6JY98