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Hgf hepatocyte growth factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24446, updated on 30-Sep-2021

Summary

Official Symbol
Hgfprovided by RGD
Official Full Name
hepatocyte growth factorprovided by RGD
Primary source
RGD:2794
See related
EnsemblRapid:ENSRNOG00000007027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HPTA
Summary
plays a role in positive regulation of cell proliferation; may promote entry into the cell cycle [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 137.5), Lung (RPKM 132.1) and 8 other tissues See more
Orthologs
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Genomic context

See Hgf in Genome Data Viewer
Location:
4q12
Exon count:
19
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (18673736..18745582, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (15435460..15505377, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene igE-binding protein-like Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2-like Neighboring gene uncharacterized LOC103692033 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene hypothetical LOC100360215

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor
Names
SF
hepatopoeitin-A
hepatopoietin-A
scatter factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017017.2NP_058713.1  hepatocyte growth factor preproprotein

    See identical proteins and their annotated locations for NP_058713.1

    Status: VALIDATED

    Source sequence(s)
    D90102, X54400
    UniProtKB/Swiss-Prot
    P17945
    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    18673736..18745582 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107017.1XP_038962945.1  hepatocyte growth factor isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  2. XM_039107016.1XP_038962944.1  hepatocyte growth factor isoform X1

    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  3. XM_039107018.1XP_038962946.1  hepatocyte growth factor isoform X2

    Related
    ENSRNOP00000009764.3, ENSRNOT00000009763.6
    Conserved Domains (4) summary
    smart00020
    Location:494718
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210288
    KR; Kringle domain
    cd00108
    Location:388470
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:40122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  4. XM_006235979.4XP_006236041.1  hepatocyte growth factor isoform X3

    Conserved Domains (5) summary
    smart00020
    Location:490714
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:206284
    KR; Kringle domain
    cd00108
    Location:384466
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:503717
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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