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Hgf hepatocyte growth factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24446, updated on 14-Oct-2018

Summary

Official Symbol
Hgfprovided by RGD
Official Full Name
hepatocyte growth factorprovided by RGD
Primary source
RGD:2794
See related
Ensembl:ENSRNOG00000007027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HPTA
Summary
plays a role in positive regulation of cell proliferation; may promote entry into the cell cycle [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 137.5), Lung (RPKM 132.1) and 8 other tissues See more
Orthologs

Genomic context

See Hgf in Genome Data Viewer
Location:
4q12
Exon count:
18
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (15435460..15505377, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (15408857..15478988, complement)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene dimethyladenosine transferase 1, mitochondrial-like Neighboring gene cadherin EGF LAG seven-pass G-type receptor 2-like Neighboring gene uncharacterized LOC103692033 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene uncharacterized LOC103692034 Neighboring gene hypothetical LOC100360215

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
animal organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to hepatocyte growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
hepatocyte growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hyaluronan metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
liver development IEA
Inferred from Electronic Annotation
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of myelination IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection regeneration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor
Names
SF
hepatopoeitin-A
hepatopoietin-A
scatter factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017017.2NP_058713.1  hepatocyte growth factor preproprotein

    See identical proteins and their annotated locations for NP_058713.1

    Status: VALIDATED

    Source sequence(s)
    D90102, X54400
    UniProtKB/Swiss-Prot
    P17945
    Related
    ENSRNOP00000009764.2, ENSRNOT00000009763.5
    Conserved Domains (5) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:508722
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    15435460..15505377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235979.3XP_006236041.1  hepatocyte growth factor isoform X1

    Conserved Domains (5) summary
    smart00020
    Location:490714
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:206284
    KR; Kringle domain
    cd00108
    Location:384466
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:503717
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    14212976..14281167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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