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Prag1 PEAK1 related kinase activating pseudokinase 1 [ Mus musculus (house mouse) ]

Gene ID: 244418, updated on 18-Sep-2024

Summary

Official Symbol
Prag1provided by MGI
Official Full Name
PEAK1 related kinase activating pseudokinase 1provided by MGI
Primary source
MGI:MGI:1196223
See related
Ensembl:ENSMUSG00000050271 AllianceGenome:MGI:1196223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NACK; Sgk223; D8Ertd82e; mFLJ00269; 9830148H23
Summary
Predicted to enable identical protein binding activity and protein kinase activity. Involved in regulation of Notch signaling pathway. Located in nucleus. Is expressed in forebrain; spinal cord; telencephalon; and vibrissa. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine adult (RPKM 9.2), mammary gland adult (RPKM 8.6) and 26 other tissues See more
Orthologs
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Genomic context

See Prag1 in Genome Data Viewer
Location:
8 A4; 8 22.78 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (36562015..36614939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (36094827..36147787)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:37091412-37091733 Neighboring gene ribosomal protein S12, pseudogene 24 Neighboring gene predicted gene, 39163 Neighboring gene STARR-positive B cell enhancer ABC_E8845 Neighboring gene STARR-seq mESC enhancer starr_21199 Neighboring gene STARR-positive B cell enhancer ABC_E5001 Neighboring gene predicted gene, 38414 Neighboring gene STARR-seq mESC enhancer starr_21203 Neighboring gene predicted gene, 39164

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00269, MGC100334

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive tyrosine-protein kinase PRAG1
Names
notch activation complex kinase
pragmin
sugen kinase 223
tyrosine-protein kinase PRAG1
tyrosine-protein kinase SgK223
NP_001413501.1
NP_766499.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426572.1NP_001413501.1  inactive tyrosine-protein kinase PRAG1

    Status: VALIDATED

    Source sequence(s)
    AC121858
    UniProtKB/Swiss-Prot
    E9QLH9, Q571I4, Q8CB68
  2. NM_172911.4NP_766499.2  inactive tyrosine-protein kinase PRAG1

    See identical proteins and their annotated locations for NP_766499.2

    Status: VALIDATED

    Source sequence(s)
    AC121858
    Consensus CDS
    CCDS22247.2
    UniProtKB/Swiss-Prot
    E9QLH9, Q571I4, Q8CB68
    Related
    ENSMUSP00000106118.2, ENSMUST00000110492.2
    Conserved Domains (2) summary
    PHA03247
    Location:387603
    PHA03247; large tegument protein UL36; Provisional
    cl21453
    Location:10941297
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    36562015..36614939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)