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Gstm2 glutathione S-transferase mu 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24424, updated on 5-Aug-2018

Summary

Official Symbol
Gstm2provided by RGD
Official Full Name
glutathione S-transferase mu 2provided by RGD
Primary source
RGD:2756
See related
Ensembl:ENSRNOG00000018937
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GSTA4
Summary
subunit of glutathione S-transferase, which may play a role in xenobiotic metabolism and response to oxidative stress [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 2814.2), Testes (RPKM 1345.5) and 5 other tissues See more

Genomic context

See Gstm2 in Genome Data Viewer
Location:
2q34
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210778041..210782807, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (230247260..230251618, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550192 Neighboring gene glutathione S-transferase mu 3-like Neighboring gene glutathione S-transferase mu 1 Neighboring gene glutathione S-transferase mu 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione binding IEA
Inferred from Electronic Annotation
more info
 
glutathione binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
 
glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
glutathione transferase activity TAS
Traceable Author Statement
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cellular detoxification of nitrogen compound IEA
Inferred from Electronic Annotation
more info
 
cellular detoxification of nitrogen compound ISO
Inferred from Sequence Orthology
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to caffeine IEA
Inferred from Electronic Annotation
more info
 
cellular response to caffeine ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
linoleic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
nitrobenzene metabolic process IEA
Inferred from Electronic Annotation
more info
 
nitrobenzene metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ryanodine-sensitive calcium-release channel activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
response to catechin IEP
Inferred from Expression Pattern
more info
PubMed 
response to genistein IEP
Inferred from Expression Pattern
more info
PubMed 
response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
xenobiotic catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic catabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intercellular bridge IEA
Inferred from Electronic Annotation
more info
 
intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase Mu 2
Names
GST 4-4
GST Yb2
GSTM2-2
Glutathione-S-transferase, mu type 2 (Yb2)
glutathione S-transferase M2
glutathione S-transferase Yb-2
glutathione S-transferase Yb2 subunit
NP_803175.1
XP_017446116.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177426.1NP_803175.1  glutathione S-transferase Mu 2

    See identical proteins and their annotated locations for NP_803175.1

    Status: PROVISIONAL

    Source sequence(s)
    J03914
    UniProtKB/Swiss-Prot
    P08010
    UniProtKB/TrEMBL
    B6DYQ2
    Related
    ENSRNOP00000025939.1, ENSRNOT00000025939.4
    Conserved Domains (3) summary
    PTZ00057
    Location:3200
    PTZ00057; glutathione s-transferase; Provisional
    cd03209
    Location:92212
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:384
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    210778041..210782807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590627.1XP_017446116.1  glutathione S-transferase Mu 2 isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    188270799..188275157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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