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Gspt1 G1 to S phase transition 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24420, updated on 18-Jan-2022

Summary

Symbol
Gspt1provided by RGD
Full Name
G1 to S phase transition 1provided by RGD
Primary source
RGD:2751
See related
Ensembl:ENSRNOG00000046271
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation. Predicted to be located in cytosol. Predicted to be part of translation release factor complex. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 355.4), Adrenal (RPKM 354.5) and 9 other tissues See more
Orthologs
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Genomic context

See Gspt1 in Genome Data Viewer
Location:
10q11
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4362528..4397215)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4313100..4347661)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 17 Neighboring gene formin-1-like Neighboring gene uncharacterized LOC120095016 Neighboring gene uncharacterized LOC108352048 Neighboring gene uncharacterized LOC100911627

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC94063

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation release factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of translational termination ISO
Inferred from Sequence Orthology
more info
 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translational termination ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of translation release factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic peptide chain release factor GTP-binding subunit ERF3A
Names
G1 to S phase transition protein 1
G1 to phase transition 1
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003978.1NP_001003978.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    See identical proteins and their annotated locations for NP_001003978.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079092
    UniProtKB/TrEMBL
    Q6AYD5
    Related
    ENSRNOP00000067103.1, ENSRNOT00000074487.3
    Conserved Domains (5) summary
    cd01883
    Location:213429
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:209633
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:6279
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:438519
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:525631
    eRF3_C_III; C-terminal domain of eRF3

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    4362528..4397215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596996.2XP_017452485.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1

    Conserved Domains (5) summary
    cd01883
    Location:212428
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    COG5256
    Location:208632
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam07145
    Location:6279
    PAM2; Ataxin-2 C-terminal region
    cd04089
    Location:437518
    eRF3_II; Domain II of the eukaryotic class II release factor
    cd03704
    Location:524630
    eRF3_C_III; C-terminal domain of eRF3
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